Regulator of microtubule dynamics protein 3 Recombinant Protein | RMDN3 recombinant protein

Recombinant Human Regulator of microtubule dynamics protein 3

Cat. Num. AAA969737

• Gene Names: RMDN3; RMD3; RMD-3; FAM82C; FAM82A2; ptpip51
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Regulator of microtubule dynamics protein 3; Recombinant Human Regulator of microtubule dynamics protein 3; Cerebral protein 10; Protein FAM82A2; Protein FAM82; CProtein tyrosine phosphatase-interacting protein 51T; CPTP-interacting protein 51; RMDN3 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-470aa; Full Length
• Sequence: MSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVARRRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVYGSRQDFLWRLARAYSDMCELTEEVSEKKSYALDGKEEAEAALEKGDESADCHLWYAVLCGQLAEHESIQRRIQSGFSFKEHVDKAIALQPENPMAHFLLGRWCYQVSHLSWLEKKTATALLESPLSATVEDALQSFLKAEELQPGFSKAGRVYISKCYRELGKNSEARWWMKLALELPDVTKEDLAIQKDLEELEVILRD

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for RMDN3 recombinant protein

Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.

Product Categories/Family for RMDN3 recombinant protein

Apoptosis

References

Molecular cloning of a novel gene expressed in human cerebral cortex.Yoshimoto M., Yazaki M., Matsumoto K., Takayama K. The secreted protein discovery initiative (SPDI) , a large-scale effort to identify novel human secreted and transmembrane proteins a bioinformatics assessment.Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.Genome Res. 13:2265-2270(2003) Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004)

NCBI and Uniprot Product Information

• NCBI GI #: 756140861
• NCBI GeneID: 55177
• NCBI Accession #: NP_001291731.1
• NCBI GenBank Nucleotide #: NM_001304802.1
• UniProt Accession #: Q96TC7; Q6ZWE9; Q96H23; Q96SD6; Q9H6G1; Q9NVQ6; A9UMZ9; B3KRR3
• Molecular Weight: 56.1 kDa
• NCBI Official Full Name: regulator of microtubule dynamics protein 3
• NCBI Official Synonym Full Names: regulator of microtubule dynamics 3
• NCBI Official Symbol: RMDN3
• NCBI Official Synonym Symbols: RMD3; RMD-3; FAM82C; FAM82A2; ptpip51
• NCBI Protein Information: regulator of microtubule dynamics protein 3
• UniProt Protein Name: Regulator of microtubule dynamics protein 3
• Protein Family: Regulator of microtubule dynamics protein
• UniProt Gene Name: RMDN3
• UniProt Synonym Gene Names: FAM82A2; FAM82C; PTPIP51; RMD-3; hRMD-3
• UniProt Entry Name: RMD3_HUMAN

Uniprot Description

FAM82A2: a single-pass membrane protein in the mitochondrial membrane. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system. Induced by EGF, TGF-beta, retinoic acid-and 1,25-Dihydroxyvitamin D(3). Two alternatively spliced human isoforms may be produced.

Protein type: Apoptosis; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: integral to membrane; microtubule; mitochondrial outer membrane; mitochondrion; nucleus; spindle pole

Molecular Function: protein binding

Biological Process: apoptosis; cell differentiation; cellular calcium ion homeostasis