Rho guanine nucleotide exchange factor 18 Recombinant Protein | ARHGEF18 recombinant protein

Recombinant Human Rho guanine nucleotide exchange factor 18 (ARHGEF18), partial

Cat. Num. AAA9423933

• Gene Names: RHO; RP4; OPN2; CSNBAD1
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Rho guanine nucleotide exchange factor 18; Recombinant Human Rho guanine nucleotide exchange factor 18 (ARHGEF18); partial; Opsin-2; ARHGEF18 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: Tris-based buffer, 50% glycerol
• Sequence Positions: Partial, 1-36aa

• Tag Info: N-terminal 6xHis-SUMO-tagged
• Preparation and Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.; Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.

Related Product Information for ARHGEF18 recombinant protein

Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.

NCBI and Uniprot Product Information

• NCBI GI #: 4506527
• NCBI GeneID: 6010
• NCBI Accession #: NP_000530.1
• NCBI GenBank Nucleotide #: NM_000539.3
• UniProt Accession #: P08100; Q16414; Q2M249
• Molecular Weight: 20.15 kDa
• NCBI Official Full Name: rhodopsin
• NCBI Official Synonym Full Names: rhodopsin
• NCBI Official Symbol: RHO
• NCBI Official Synonym Symbols: RP4; OPN2; CSNBAD1
• NCBI Protein Information: rhodopsin
• UniProt Protein Name: Rhodopsin
• Protein Family: Rho guanine nucleotide exchange factor
• UniProt Gene Name: RHO
• UniProt Synonym Gene Names: OPN2

NCBI Description

Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]

Uniprot Description

Rhodopsin: a G-protein coupled receptor. The light-absorbing visual pigment in Rod photoreceptor cells. Mediates vision in dim light. Consists of the apoprotein, opsin, covalently linked to cis-retinal. Defects in RHO are a cause of autosomal retinitis pigmentosa and congenital stationary night blindness.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: Golgi apparatus; Golgi membrane; integral to plasma membrane; photoreceptor inner segment; photoreceptor outer segment; plasma membrane

Molecular Function: G-protein coupled photoreceptor activity; G-protein coupled receptor activity; protein binding

Biological Process: absorption of visible light; G-protein coupled receptor protein signaling pathway; phototransduction, visible light; regulation of rhodopsin mediated signaling; retinoid metabolic process; rhodopsin mediated signaling

Disease: Fundus Albipunctatus; Night Blindness, Congenital Stationary, Autosomal Dominant 1; Retinitis Pigmentosa 4