Western Blot (WB)
(Fig. Western Blot analysis of various cells using Fliz1 Polyclonal Antibody.)
Rabbit anti-Human Fliz1 Polyclonal Antibody | anti-FLIZ1 antibody
Fliz1 Polyclonal Antibody
Gene Names
ZC3H8; Fliz1; ZC3HDC8
Reactivity
Human
Applications
Western Blot, Immunohistochemistry, ELISA
Purity
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
Fliz1; Polyclonal Antibody; Fliz1 Polyclonal Antibody; Rabbit Anti-Fliz1 Polyclonal Antibody; ZC3H8; ZC3HDC8; Zinc finger CCCH domain-containing protein 8; anti-FLIZ1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Fliz1 Polyclonal Antibody detects endogenous levels of Fliz1 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid; PBS Containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
291
Applicable Applications for anti-FLIZ1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA)
Application Notes
WB: 1:500-1:2000
IHC-P: 1:100-1:300
ELISA: 1:40000
IHC-P: 1:100-1:300
ELISA: 1:40000
Immunogen
Synthesized peptide derived from the internal region of human Fliz1 at AA range: 50-130
Preparation and Storage
Stable for one year at -20 degree C from date of shipment.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Western Blot (WB)
(Fig. Western Blot analysis of various cells using Fliz1 Polyclonal Antibody.)
Western Blot (WB)
(Fig. Western Blot analysis of various cells using Fliz1 Polyclonal Antibody.)
Related Product Information for anti-FLIZ1 antibody
ZC3H8 is a Protein Coding gene. Zinc finger CCCH domain-containing protein 8 acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5-AGGTCTC-3 sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include poly (A) RNA binding and sequence-specific DNA binding. An important paralog of this gene is ZC3H4.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
zinc finger CCCH domain-containing protein 8
NCBI Official Synonym Full Names
zinc finger CCCH-type containing 8
NCBI Official Symbol
ZC3H8
NCBI Official Synonym Symbols
Fliz1; ZC3HDC8
NCBI Protein Information
zinc finger CCCH domain-containing protein 8
UniProt Protein Name
Zinc finger CCCH domain-containing protein 8
UniProt Gene Name
ZC3H8
UniProt Synonym Gene Names
ZC3HDC8
UniProt Entry Name
ZC3H8_HUMAN
Uniprot Description
ZC3H8: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2q13
Cellular Component: Cajal body; transcription elongation factor complex; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; metal ion binding; transcription factor activity
Biological Process: response to antibiotic; apoptosis; snRNA transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; T cell homeostasis; negative regulation of T cell differentiation in the thymus; negative regulation of transcription, DNA-dependent; snRNA transcription from RNA polymerase III promoter
Similar Products
Product Notes
The FLIZ1 zc3h8 (Catalog #AAA9702057) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Fliz1 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Fliz1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA). WB: 1:500-1:2000 IHC-P: 1:100-1:300 ELISA: 1:40000. Researchers should empirically determine the suitability of the FLIZ1 zc3h8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fliz1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
