Rabbit Rhodopsin Polyclonal Antibody | anti-RHO antibody

Rhodopsin Polyclonal Antibody

Cat. Num. AAA2539162

• Gene Names: RHO; RP4; OPN2; CSNBAD1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Affinity Purification
• Synonyms: Rhodopsin; Polyclonal Antibody; Rhodopsin Polyclonal Antibody; RHO; OPN2; Opsin-2; anti-RHO antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Concentration: 1mg/mL (varies by lot)

• Applicable Applications for anti-RHO antibody: WB, IHC-p, ELISA
• Application Notes: WB 1:500-2000; IHC 1:100-1:300; ELISA 1:5000
• Immunogen: Synthesized peptide derived from human Rhodopsin around the non-phosphorylation site of S334.
• Calculated MW: 39 kDa
• Observed MW: 42 kDa
• Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.
• Preparation and Storage: Store at -20°C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of COLO205 cells with Rhodopsin Polyclonal Antibody.)

Related Product Information for anti-RHO antibody

Retinitis pigmentosa is an inherited progressive disease which is a majorcause of blindness in western communities. It can be inherited as anautosomal dominant, autosomal recessive, or X-linked recessive disorder.In the autosomal dominant form,which comprises about 25% of totalcases, approximately 30% of families have mutations in the geneencoding the rod photoreceptor-specific protein rhodopsin. This is thetransmembrane protein which, when photoexcited, initiates the visualtransduction cascade. Defects in this gene are also one of the causes ofcongenital stationary night blindness.RHO (Rhodopsin) is a ProteinCoding gene. Diseases associated with RHO include Night Blindness,Congenital Stationary, Autosomal Dominant 1 and Retinitis Pigmentosa4, Autosomal Dominant Or Recessive. Among its related pathways are thevisual cycle I (vertebrates) and Phototransduction. GO annotations relatedto this gene include G-protein coupled receptor activity and photoreceptoractivity. An important paralog of this gene is OPN1SW

NCBI and Uniprot Product Information

• NCBI GI #: 4506527
• NCBI GeneID: 6010
• NCBI Accession #: NP_000530.1
• NCBI GenBank Nucleotide #: NM_000539.3
• NCBI Official Full Name: rhodopsin
• NCBI Official Synonym Full Names: rhodopsin
• NCBI Official Symbol: RHO
• NCBI Official Synonym Symbols: RP4; OPN2; CSNBAD1
• NCBI Protein Information: rhodopsin
• UniProt Protein Name: Rhodopsin
• Protein Family: Rhodopsin
• UniProt Gene Name: RHO
• UniProt Synonym Gene Names: OPN2
• UniProt Entry Name: OPSD_HUMAN

NCBI Description

Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008]

Uniprot Description

Rhodopsin: a G-protein coupled receptor. The light-absorbing visual pigment in Rod photoreceptor cells. Mediates vision in dim light. Consists of the apoprotein, opsin, covalently linked to cis-retinal. Defects in RHO are a cause of autosomal retinitis pigmentosa and congenital stationary night blindness.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3q21-q24

Cellular Component: Golgi apparatus; Golgi membrane; integral to plasma membrane; intercellular junction; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; rough endoplasmic reticulum membrane

Molecular Function: G-protein coupled receptor activity; metal ion binding; photoreceptor activity; protein binding; retinal binding

Biological Process: absorption of visible light; G-protein coupled receptor protein signaling pathway; organelle organization and biogenesis; photoreceptor cell maintenance; phototransduction, visible light; protein amino acid phosphorylation; protein-chromophore linkage; red, far-red light phototransduction; regulation of rhodopsin mediated signaling; retina development in camera-type eye; retinoid metabolic process; rhodopsin mediated signaling; visual perception

Disease: Fundus Albipunctatus; Night Blindness, Congenital Stationary, Autosomal Dominant 1; Retinitis Pigmentosa 4