Stem Cell Factor Active Protein | KITLG active protein

Recombinant Protein, Stem Cell Factor Rat

Cat. Num. AAA555455

• Gene Names: KITLG; SF; MGF; SCF; DCUA; FPH2; FPHH; KL-1; Kitl; SHEP7
• Reactivity: Rat
• Synonyms: Stem Cell Factor; Recombinant Protein; Stem Cell Factor Rat; KITLG active protein

• Reactivity: Rat
• Sequence Length: 5

• Biological Activity: The ED50 as determined by the dose-dependant stimulation of Human TF-1 cells is < 2 ng/ml, corresponding to a Specific Activity of 5x105 IU/mg.
• Preparation and Storage: Store at 4-8 degrees

Related Product Information for KITLG active protein

SCF is a growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and other hematopoietic progenitor cells. One of its roles is to change the BFU-E (burst-forming unit-erythroid) cells, which are the earliest erythrocyte precursors in the erythrocytic series, into the CFU-E (colony-forming unit-erythroid).

Product Categories/Family for KITLG active protein

Stem Cell Factor/Kit Ligand

NCBI and Uniprot Product Information

• NCBI GI #: 1750378
• NCBI GeneID: 4254
• Molecular Weight: 26,667 Da
• NCBI Official Full Name: stem cell factor, partial
• NCBI Official Synonym Full Names: KIT ligand
• NCBI Official Symbol: KITLG
• NCBI Official Synonym Symbols: SF; MGF; SCF; DCUA; FPH2; FPHH; KL-1; Kitl; SHEP7
• NCBI Protein Information: kit ligand
• UniProt Protein Name: Kit ligand
• Protein Family: Kit ligand
• UniProt Gene Name: KITLG
• UniProt Synonym Gene Names: MGF; SCF; MGF; SCF; sKITLG
• UniProt Entry Name: SCF_HUMAN

Uniprot Description

SCF: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: cytoplasm; extracellular region; filopodium; lamellipodium; plasma membrane

Molecular Function: phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: cell proliferation; embryonic hemopoiesis; male gonad development; MAPKKK cascade; phosphoinositide-mediated signaling; positive regulation of DNA replication; regulation of phosphoinositide 3-kinase cascade; signal transduction

Disease: Deafness, Autosomal Dominant 69; Hyperpigmentation, Familial Progressive, 2; Skin/hair/eye Pigmentation, Variation In, 7