Chicken Stem Cell Factor ELISA Kit | SCF elisa kit

Chicken Stem Cell Factor ELISA Kit

Cat. Num. AAA765307

• Gene Names: KITLG; SF; MGF; SCF; DCUA; FPH2; FPHH; KL-1; Kitl; SHEP7
• Reactivity: Chicken
• Synonyms: Stem Cell Factor; Chicken Stem Cell Factor ELISA Kit; SCF elisa kit

• Reactivity: Chicken
• Sequence Length: 37

• Samples: Serum, plasma and other biological fluids.
• Assay Type: Sandwich ELISA, Double Antibody
• Detection Range: 0.313-20ng/ml
• Sensitivity: 0.188ng/ml
• Preparation and Storage: Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).

Typical Standard Curve

NCBI and Uniprot Product Information

• NCBI GI #: 1246100
• NCBI GeneID: 4254
• Molecular Weight: 26,667 Da
• NCBI Official Full Name: stem cell factor, partial
• NCBI Official Synonym Full Names: KIT ligand
• NCBI Official Symbol: KITLG
• NCBI Official Synonym Symbols: SF; MGF; SCF; DCUA; FPH2; FPHH; KL-1; Kitl; SHEP7
• NCBI Protein Information: kit ligand
• UniProt Protein Name: Kit ligand
• UniProt Gene Name: KITLG
• UniProt Synonym Gene Names: MGF; SCF; MGF; SCF; sKITLG
• UniProt Entry Name: SCF_HUMAN

NCBI Description

This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SCF: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: cytoplasm; cytoskeleton; extracellular region; extracellular space; integral to membrane; plasma membrane

Molecular Function: cytokine activity; growth factor activity; protein binding; stem cell factor receptor binding

Biological Process: activation of MAPKK activity; axon guidance; cell adhesion; cell proliferation; embryonic hemopoiesis; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; germ cell programmed cell death; innate immune response; insulin receptor signaling pathway; male gonad development; MAPKKK cascade; negative regulation of mast cell apoptosis; nerve growth factor receptor signaling pathway; neural crest cell migration; ovarian follicle development; phosphoinositide-mediated signaling; positive regulation of DNA replication; positive regulation of leukocyte migration; positive regulation of MAP kinase activity; positive regulation of melanocyte differentiation; positive regulation of myeloid leukocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of Ras protein signal transduction; Ras protein signal transduction; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway

Disease: Hyperpigmentation, Familial Progressive, 2; Skin/hair/eye Pigmentation, Variation In, 7