Rabbit anti-Human, Mouse TXNRD1 Antibody | anti-TXNRD1 antibody

TXNRD1 Antibody

Cat. Num. AAA8502306

• Gene Names: TXNRD1; TR; TR1; TXNR; TRXR1; GRIM-12
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Synonyms: TXNRD1; TXNRD1 Antibody; anti-TXNRD1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Isotype: IgG
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. (varies by lot)
• Sequence Length: 649

• Applicable Applications for anti-TXNRD1 antibody: Western Blot (WB), Immunohistochemistry (IHC). Not yet tested in other applications. Determining optimal working dilutions by titration test.
• Application Notes: WB: 1/500-1/2000, IHC: 1/50-1/200
• Immunogen: Recombinant protein of human TXNRD1.
• Preparation and Storage: Store at 4 degree C, for long term storage, store at -20 degree C.

Western Blot

(Western Blot analysis using TXNRD1 antibody (MBS8502306) against HepG2, BxPC-3 cell lysate and mouse heart lysate.)

NCBI and Uniprot Product Information

• NCBI GI #: 148277071
• NCBI GeneID: 7296
• NCBI Accession #: NP_001087240.1
• NCBI GenBank Nucleotide #: NM_001093771.2
• UniProt Accession #: Q16881; Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780
• Molecular Weight: 65kDa
• NCBI Official Full Name: thioredoxin reductase 1, cytoplasmic isoform 5
• NCBI Official Synonym Full Names: thioredoxin reductase 1
• NCBI Official Symbol: TXNRD1
• NCBI Official Synonym Symbols: TR; TR1; TXNR; TRXR1; GRIM-12
• NCBI Protein Information: thioredoxin reductase 1, cytoplasmic
• UniProt Protein Name: Thioredoxin reductase 1, cytoplasmic
• Protein Family: Thioredoxin reductase
• UniProt Gene Name: TXNRD1
• UniProt Synonym Gene Names: GRIM12; KDRF; TR; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein

NCBI Description

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]

Uniprot Description

Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.