Human Thioredoxin reductase 1, cytoplasmic ELISA Kit | TXNRD1 elisa kit

Human Thioredoxin reductase 1, cytoplasmic ELISA Kit

Cat. Num. AAA2880624

• Gene Names: TXNRD1; TR; TR1; TXNR; TRXR1; GRIM-12
• Reactivity: Human
• Synonyms: Thioredoxin reductase 1; cytoplasmic; Human Thioredoxin reductase 1; cytoplasmic ELISA Kit; TR; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12; TXNRD1 elisa kit

• Reactivity: Human
• Sequence Length: 649

• Assay Type: Sandwich
• Detection Range: 0.312-20 ng/mL
• Sensitivity: 0.156 ng/mL
• Intra-Assay CV: <=4.5%
• Inter-Assay CV: <=8.9%
• Recovery: 106%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 148277071
• NCBI GeneID: 7296
• NCBI Accession #: NP_001087240.1
• NCBI GenBank Nucleotide #: NM_001093771.2
• UniProt Accession #: Q16881; Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780
• Molecular Weight: 50,873 Da
• NCBI Official Full Name: thioredoxin reductase 1, cytoplasmic isoform 3
• NCBI Official Synonym Full Names: thioredoxin reductase 1
• NCBI Official Symbol: TXNRD1
• NCBI Official Synonym Symbols: TR; TR1; TXNR; TRXR1; GRIM-12
• NCBI Protein Information: thioredoxin reductase 1, cytoplasmic
• UniProt Protein Name: Thioredoxin reductase 1, cytoplasmic
• Protein Family: Thioredoxin reductase
• UniProt Gene Name: TXNRD1
• UniProt Synonym Gene Names: GRIM12; KDRF; TR; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein
• UniProt Entry Name: TRXR1_HUMAN

NCBI Description

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

TRXR1: a cytoplasmic pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity.

Protein type: Nucleotide Metabolism - pyrimidine; Nuclear receptor co-regulator; EC 1.8.1.9; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q23-q24.1

Cellular Component: cytosol; mitochondrion; nucleus

Molecular Function: electron carrier activity; FAD binding; protein binding; protein disulfide oxidoreductase activity; thioredoxin-disulfide reductase activity

Biological Process: cell proliferation; cell redox homeostasis; cellular lipid metabolic process; gene expression; mesoderm formation; nucleobase, nucleoside and nucleotide interconversion; nucleobase, nucleoside and nucleotide metabolic process; response to reactive oxygen species; selenium metabolic process; signal transduction; transcription initiation from RNA polymerase II promoter