TC-PTP/PTPN2 recombinant protein

Recombinant Human TC-PTP/PTPN2 (C-6His)

Cat. Num. AAA2569164

• Gene Names: PTPN2; PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: TC-PTP/PTPN2; Recombinant Human TC-PTP/PTPN2 (C-6His); PTP2; PTPN2; PTPTPTN2; TCELLPTP; TCPTP; TC-PTP; TC-PTP/PTPN2 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Supplied as a 0.2um filtered solution of 20mM HEPES, 300Mm NaCl, 1mM DTT, 10% Glycerol, pH7.4.
• Sequence: Thr2-Asn314

• Species: Human
• Tag: C-6His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Human Tyrosine-protein phosphatase non-receptor type 2 is produced by our E Coli expression system and the target gene encoding Thr2-Asn314 is expressed with a 6His tag at the C-terminus.
• Preparation and Storage: Store at < -20 degree C, stable for 6 months. Please minimize freeze-thaw cycles.; This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20 degree C.

SDS-Page

Related Product Information for TC-PTP/PTPN2 recombinant protein

Tyrosine-protein phosphatase non-receptor type 2 (PTPN2), also known as PTPT and TC-PTP, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. Members of the protein tyrosine phosphatase (PTP) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP/PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP/PTPN2 plays a role of tumor suppressor and may modulate response to treatment. TC-PTP/PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation.TC-PTP/PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.

Product Categories/Family for TC-PTP/PTPN2 recombinant protein

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 229462762
• NCBI GeneID: 5771
• UniProt Accession #: P17706; Q96AU5; Q96HR2; A8K955; A8MXU3; K7ENG3
• Molecular Weight: 415
• NCBI Official Full Name: Tyrosine-protein phosphatase non-receptor type 2
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 2
• NCBI Official Symbol: PTPN2
• NCBI Official Synonym Symbols: PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 2; T-cell protein tyrosine phosphatase
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 2
• UniProt Gene Name: PTPN2
• UniProt Synonym Gene Names: PTPT; TCPTP
• UniProt Entry Name: PTN2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

Uniprot Description

PTPN2: a type 2 non-receptor phospho-tyrosine-protein phosphatase (PTP). Two alternatively spliced isoforms are differenyially expressed. Isoform A is a major PTP expressed in human tissues, while isoform B is expressed mainly in T-cells and in placenta.

Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 18p11.3-p11.2

Cellular Component: nucleoplasm; endoplasmic reticulum; ER-Golgi intermediate compartment; plasma membrane; nucleus

Molecular Function: integrin binding; protein binding; syntaxin binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; protein kinase binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat1 protein; cytokine and chemokine mediated signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of T cell receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of chemotaxis; glucose homeostasis; negative regulation of cell proliferation; positive regulation of gluconeogenesis; negative regulation of macrophage differentiation; negative regulation of inflammatory response; B cell differentiation; negative regulation of tyrosine phosphorylation of Stat3 protein; insulin receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat6 protein; erythrocyte differentiation; T cell differentiation