Prolactin Receptor/PRLR Recombinant Protein | PRLR recombinant protein

Recombinant Mouse Prolactin Receptor/PRLR Protein (C-Fc)

Cat. Num. AAA2557452

• Gene Names: Prlr; Pr-1; Pr-3; AI987712; Prlr-rs1
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Prolactin Receptor/PRLR; Recombinant Mouse Prolactin Receptor/PRLR Protein (C-Fc); Prolactin receptor; PRL-R; Prlr; Prolactin R; PRLR; PRLR recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
• Sequence: Gln20-Asp229
• Sequence Length: 303

• Species: Mouse
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-Fc
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for PRLR recombinant protein

Protein Construction: Recombinant Mouse Prolactin receptor is produced by our mammalian expression system and the target gene encoding Gln20-Asp229 is expressed with a Fc tag at the C-terminus.

Background: The prolactin receptor (PRLR) is a member of the class I cytokine/lactogen receptor family which mediates the diverse cellular actions of prolactin in several tissues. PRLRs are expressed in normal and neoplastic human breast tissue, and in most breast cancer cells. PRLR contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region required for the activation of the Jak2-Stat5 signal transduction pathway by Prl which is essential for transcriptional activation of all known prolactin regulated genes. PRLRs have also been observed in ovarian follicular cells of mice, pigs, sheep, deer, and humans, as well as in luteal tissue in cow and horse ovaries. Furthermore, PRLR knockout mice exhibit failure of embryonic implantation, reduced number of mature oocytes, and low fertilization rates. Knockout females also display a reduced number of primary follicles.

NCBI and Uniprot Product Information

• NCBI GI #: 359339025
• NCBI GeneID: 19116
• NCBI Accession #: NP_001240711.1
• NCBI GenBank Nucleotide #: NP_001240711.1
• UniProt Accession #: Q08501
• Molecular Weight: Molecular Mass: 51.7kDa; Actual Protein Molecular Mass: 62-88kDa
• NCBI Official Full Name: prolactin receptor isoform 3
• NCBI Official Synonym Full Names: prolactin receptor
• NCBI Official Symbol: Prlr
• NCBI Official Synonym Symbols: Pr-1; Pr-3; AI987712; Prlr-rs1
• NCBI Protein Information: prolactin receptor
• UniProt Protein Name: Prolactin receptor
• Protein Family: Prolactin receptor
• UniProt Gene Name: Prlr
• UniProt Synonym Gene Names: PRL-R
• UniProt Entry Name: PRLR_MOUSE

Uniprot Description

PRLR: receptor for the anterior pituitary hormone prolactin and placental lactogen I and II. Interacts with Cyclophilin A, differentially regulating various signaling pathways from the PrlR. Prolactin signaling is attenuated by threonine and tyrosine phosphorylation. Two alternative splice isoforms have been identified.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; intracellular

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; peptide hormone binding; metal ion binding; protein kinase binding; prolactin receptor activity

Biological Process: regulation of cell adhesion; lactation; transmembrane receptor protein tyrosine kinase activation (dimerization); regulation of epithelial cell differentiation; JAK-STAT cascade