Western Blot (WB)
(TRIM11 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TRIM11 antibody detected the TRIM11 protein (arrow).)
Rabbit TRIM11 Polyclonal Antibody | anti-TRIM11 antibody
TRIM11 Antibody (C-term)
IHC-P~~1:10~50
Western Blot (WB)
(TRIM11 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TRIM11 antibody detected the TRIM11 protein (arrow).)
Western Blot (WB)
(TRIM11 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TRIM11 antibody detected the TRIM11 protein (arrow).)
Immunohistochemistry (IHC)
(TRIM11 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRIM11 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(TRIM11 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRIM11 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,
and a coiled-coil region. This protein localizes to the nucleus and
the cytoplasm. Its function has not been identified. [provided by
RefSeq].
Hong, S.J., et al. Biochem. Biophys. Res. Commun. 368(3):650-655(2008)
Uchil, P.D., et al. PLoS Pathog. 4 (2), E16 (2008) :
Ishikawa, H., et al. FEBS Lett. 580(20):4784-4792(2006)
Cooper, S.T., et al. BMC Genet. 6, 43 (2005) :
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
TRIM11: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. Belongs to the TRIM/RBCC family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.-; Ubiquitin conjugating system; EC 6.3.2.19; Ligase; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 1q42.13
Cellular Component: cytoplasm; nucleus
Molecular Function: protein domain specific binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity; transcription factor binding; ligase activity
Biological Process: negative regulation of viral transcription; positive regulation of virion penetration into host cell; negative regulation of virion penetration into host cell; innate immune response; protein ubiquitination; negative regulation of transcription, DNA-dependent; defense response to virus; negative regulation of neurogenesis
Research Articles on TRIM11
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Product Notes
The TRIM11 trim11 (Catalog #AAA9206358) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 300-329. The TRIM11 Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's TRIM11 can be used in a range of immunoassay formats including, but not limited to, WB, IHC-P, E. WB~~1:1000 IHC-P~~1:10~50. Researchers should empirically determine the suitability of the TRIM11 trim11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRIM11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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