Peroxiredoxin 6 Recombinant Protein | PRDX6 recombinant protein

Peroxiredoxin 6 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8120762

• Gene Names: PRDX6; PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; HEL-S-128m
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Peroxiredoxin 6; Peroxiredoxin 6 Protein; Human; Recombinant (His Tag); Human Peroxiredoxin 6/PRDX6 Protein (His Tag); 1-Cys Protein; aiPLA2 Protein; AOP2 Protein; HEL-S-128m Protein; NSGPx Protein; p29 Protein; PRX Protein; peroxiredoxin 6; PRDX6 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Pro224

• Species: Human
• Predicted N Terminal: Met
• Tag: N-His
• Protein Construction: A DNA sequence encoding the human PRDX6 (P30041)(Met 1-Pro 224) was expressed, with a polyhistidine tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for PRDX6 recombinant protein

Background: PRDX6, a member of antioxidant protein superfamily, plays an important role in oxidative stress, catabolism of lipids and phospholipid lipisomes. Peroxiredoxin 6 (PRDX6) is involved in redox regulation of the cell and is thought to be protective against oxidant injury. Peroxiredoxin 6 (PRDX6) is a bifunctional protein with both glutathione peroxidase (GPx) and iPLA2 activities, which are concomitantly increased with the expression of PRDX6. PRDX6 promoted lung tumor growth in an in vivo allograft model.

NCBI and Uniprot Product Information

• NCBI GI #: 1718024
• NCBI GeneID: 9588
• UniProt Accession #: P30041; P32077; Q5TAH4; Q5ZEZ8; A8JZY7
• Molecular Weight: Observed: 27kDa; Calculated: 25kDa
• NCBI Official Full Name: Peroxiredoxin-6
• NCBI Official Synonym Full Names: peroxiredoxin 6
• NCBI Official Symbol: PRDX6
• NCBI Official Synonym Symbols: PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; HEL-S-128m
• NCBI Protein Information: peroxiredoxin-6; 1-Cys PRX; 24 kDa protein; 1-Cys peroxiredoxin; antioxidant protein 2; liver 2D page spot 40; red blood cells page spot 12; non-selenium glutathione peroxidase; acidic calcium-independent phospholipase A2; epididymis secretory sperm bindi
• UniProt Protein Name: Peroxiredoxin-6
• Protein Family: Peroxiredoxin
• UniProt Gene Name: PRDX6
• UniProt Synonym Gene Names: AOP2; KIAA0106; 1-Cys PRX; aiPLA2; NSGPx
• UniProt Entry Name: PRDX6_HUMAN

NCBI Description

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

Uniprot Description

PRDX6: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. Belongs to the AhpC/TSA family. Rehydrin subfamily.

Protein type: Amino Acid Metabolism - phenylalanine; Oxidoreductase; Energy Metabolism - methane; EC 1.11.1.9; EC 1.11.1.15; Phospholipase

Chromosomal Location of Human Ortholog: 1q25.1

Cellular Component: extracellular space; membrane; lysosome; cytoplasmic membrane-bound vesicle; cytoplasm; cytosol

Molecular Function: antioxidant activity; phospholipase A2 activity; protein binding; peroxiredoxin activity; glutathione peroxidase activity

Biological Process: response to reactive oxygen species; phospholipid catabolic process; hydrogen peroxide catabolic process; response to oxidative stress