Western Blot (WB)
(Western Blot analysis of PATZ1 expression in transfected 293T cell line by PATZ1 polyclonal antibody. Lane 1: ZNF278 transfected lysate (59.07kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human ZNF278 Polyclonal Antibody | anti-PATZ1 antibody
ZNF278 (Zinc Finger Protein 278, POZ-, AT hook-, and Zinc Finger-containing Protein 1, PATZ1, PATZ, BTB/POZ Domain Zinc Finger Transcription Factor, Protein Kinase A RI Subunit alpha-associated Protein, RIAZ, Zinc Finger and BTB Domain-containing Protein
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: Immunofluorescence: 10ug/ml
Western Blot (WB)
(Western Blot analysis of PATZ1 expression in transfected 293T cell line by PATZ1 polyclonal antibody. Lane 1: ZNF278 transfected lysate (59.07kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of PATZ1 expression in transfected 293T cell line by PATZ1 polyclonal antibody. Lane 1: ZNF278 transfected lysate (59.07kD). Lane 2: Non-transfected lysate.)
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to ZNF278 on HeLa cell. [antibody concentration 10ug/ml])
Immunofluorescence (IF)
(Immunofluorescence of purified antibody to ZNF278 on HeLa cell. [antibody concentration 10ug/ml])
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PATZ1: Transcriptional repressor. A chromosomal aberration involving PATZ1 is associated with small round cell sarcoma. Translocation t(1;22)(p36.1;q12) with EWSR1. Belongs to the krueppel C2H2-type zinc-finger protein family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; C2H2-type zinc finger protein; DNA-binding; Oncoprotein
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: DNA binding; metal ion binding; chromatin binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; male gonad development; spermatogenesis; negative regulation of transcription, DNA-dependent; T cell differentiation
Research Articles on PATZ1
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Product Notes
The PATZ1 patz1 (Catalog #AAA642606) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ZNF278 (Zinc Finger Protein 278, POZ-, AT hook-, and Zinc Finger-containing Protein 1, PATZ1, PATZ, BTB/POZ Domain Zinc Finger Transcription Factor, Protein Kinase A RI Subunit alpha-associated Protein, RIAZ, Zinc Finger and BTB Domain-containing Protein reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ZNF278 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Suitable for use in Immunofluorescence and Western Blot. Dilution: Immunofluorescence: 10ug/ml. Researchers should empirically determine the suitability of the PATZ1 patz1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MERVNDASCG PSGCYTYQVS RHSTEMLHNL NQQRKNGGRF CDVLLRVGDE SFPAHRAVLA ACSEYFESVF SAQLGDGGAA DGGPADVGGA TAAPGGGAGG SRELEMHTIS SKVFGDILDF AYTSRIVVRL ESFPELMTAA KFLLMRSVIE ICQEVIKQSN VQILVPPARA DIMLFRPPGT SDLGFPLDMT NGAALAANSN GIAGSMQPEE EAARAAGAAI AGQASLPVLP GVDRLPMVAG PLSPQLLTSP FPSVASSAPP LTGKRGRGRP RKANLLDSMF GSPGGLREAG ILPCGLCGKV FTDANRLRQH EAQHGVTSLQ LGYIDLPPPR LGENGLPISE DPDGPRKRSR TRKQVACEIC GKIFRDVYHL NRHKLSHSGE KPYSCPVCGL RFKRKDRMSY HVRSHDGSVG KPYICQSCGK GFSRPDHLNG HIKQVHTSER PHKCQVWVGS SSGLPPLEPL PSDLPSWDFA QPALWRSSHS VPDTAFSLSL KKSFPALENL GPAHSSNTLF CPAPPGYLRQ GWTTPEGSRA FTQWPVG. It is sometimes possible for the material contained within the vial of "ZNF278, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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