Rabbit ZFHX3 / ATBF1 Polyclonal Antibody | anti-ZFHX3 / ATBF1 antibody

Anti-ZFHX3 / ATBF1 Antibody IHC-plus

Cat. Num. AAA2400263

• Gene Names: ZFHX3; ATBT; ATBF1; ZNF927
• Reactivity: Mouse, Rat, Human
• Applications: Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Western Blot, Immunoprecipitation
• Purity: Affinity purified
• Synonyms: ZFHX3 / ATBF1; Polyclonal Antibody; Anti-ZFHX3 / ATBF1 Antibody IHC-plus; Rabbit Polyclonal (IgG) to Human ZFHX3 / ATBF1; Human ZFHX3 / ATBF1; ZFHX3; AT motif-binding factor; Zinc finger homeobox 3; ZNF927; ZFH-3; Zinc finger homeobox protein 3; AT motif-binding factor 1; ATBF1; ATBT; anti-ZFHX3 / ATBF1 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat, Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: human ZFHX3 / ATBF1
• Purity/Purification: Affinity purified
• Form/Format: PBS, pH 7.2, 50% glycerol
• Sequence Length: 3703

• Applicable Applications for anti-ZFHX3 / ATBF1 antibody: Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: ICC (1:500); IF (1:500); IHC-P (1:100); WB (1:2000)
• Immunogen: ZFHX3 / ATBF1 antibody was raised against recombinant region of human ATBF1 (2107-2147 aa.) corresponding to the identical amino acid sequence of mouse ATBF1 (2114-2154 aa.).
• Immunogen Description: Recombinant region of human ATBF1 (2107-2147 aa.) corresponding to the identical amino acid sequence of mouse ATBF1 (2114-2154 aa.).
• Immunogen Type: Recombinant protein
• Target Species: Human
• Preparation and Storage: Store at -20 degree C.

Immunohistochemistry (IHC)

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Immunohistochemistry - Paraffin (IHC)

(Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry - Paraffin (IHC)

(Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunocytochemistry (ICC)

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Western Blot (WB)

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Immunoprecipitation (IP)

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Related Product Information for anti-ZFHX3 / ATBF1 antibody

ZFHX3 Antibody, AT motif-binding factor Antibody, Zinc finger homeobox 3 Antibody, ZNF927 Antibody, ZFH-3 Antibody, Zinc finger homeobox protein 3 Antibody, AT motif-binding factor 1 Antibody, ATBF1 Antibody, ATBT Antibody Description: ZFHX3 / ATBF1 is a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1).

NCBI and Uniprot Product Information

• NCBI GI #: 118498345
• NCBI GeneID: 463
• NCBI Accession #: NP_008816.3
• NCBI GenBank Nucleotide #: NM_006885.3
• UniProt Accession #: Q15911; O15101; Q13719; D3DWS8
• Molecular Weight: 306,664 Da
• NCBI Official Full Name: zinc finger homeobox protein 3 isoform A
• NCBI Official Synonym Full Names: zinc finger homeobox 3
• NCBI Official Symbol: ZFHX3
• NCBI Official Synonym Symbols: ATBT; ATBF1; ZNF927
• NCBI Protein Information: zinc finger homeobox protein 3
• UniProt Protein Name: Zinc finger homeobox protein 3
• UniProt Gene Name: ZFHX3
• UniProt Synonym Gene Names: ATBF1; ZFH-3
• UniProt Entry Name: ZFHX3_HUMAN

NCBI Description

This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

ATBF1: Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down- regulates the MUC5AC promoter in gastric cancer. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor; C2H2-type zinc finger protein; Cell development/differentiation; Mitochondrial

Chromosomal Location of Human Ortholog: 16q22.3

Cellular Component: cytoplasm; intracellular membrane-bound organelle; mitochondrion; nuclear body; nucleolus; nucleoplasm; nucleus; transcription factor complex

Molecular Function: enzyme binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity; zinc ion binding

Biological Process: brain development; cell cycle arrest; circadian regulation of gene expression; muscle development; negative regulation of myoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of myoblast differentiation; positive regulation of transcription, DNA-dependent; regulation of neuron differentiation; regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter

Disease: Prostate Cancer