Rabbit anti-Human, Mouse ZFHX3 Polyclonal Antibody | anti-ZFHX3 antibody

ZFHX3 Antibody

Cat. Num. AAA9414810

• Gene Names: ZFHX3; ATBT; ATBF1; ZNF927
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: ZFHX3; Polyclonal Antibody; ZFHX3 Antibody; Zinc finger homeodomain protein 3; ZFH-3; Alpha-fetoprotein enhancer-binding protein; AT motif-binding factor; AT-binding transcription factor 1; anti-ZFHX3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total ZFHX3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 2789

• Applicable Applications for anti-ZFHX3 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50~1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human ZFHX3.
• Target Name: ZFHX3
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ZFHX3 antibody.)

Related Product Information for anti-ZFHX3 antibody

Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer.Miura Y., J. Biol. Chem. 270:26840-26848(1995).Morinaga T., Mol. Cell. Biol. 11:6041-6049(1991).Martin J., Nature 432:988-994(2004).

Product Categories/Family for anti-ZFHX3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 258613987
• NCBI GeneID: 463
• NCBI Accession #: NP_001158238.1
• NCBI GenBank Nucleotide #: NM_001164766.1
• UniProt Accession #: Q15911; O15101; Q13719; D3DWS8
• Molecular Weight: 306,664 Da
• NCBI Official Full Name: zinc finger homeobox protein 3 isoform B
• NCBI Official Synonym Full Names: zinc finger homeobox 3
• NCBI Official Symbol: ZFHX3
• NCBI Official Synonym Symbols: ATBT; ATBF1; ZNF927
• NCBI Protein Information: zinc finger homeobox protein 3
• UniProt Protein Name: Zinc finger homeobox protein 3
• Protein Family: Zinc finger homeobox protein
• UniProt Gene Name: ZFHX3
• UniProt Synonym Gene Names: ATBF1; ZFH-3
• UniProt Entry Name: ZFHX3_HUMAN

NCBI Description

This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

ATBF1: Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down- regulates the MUC5AC promoter in gastric cancer. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Transcription factor; Cell development/differentiation; DNA-binding; Mitochondrial

Chromosomal Location of Human Ortholog: 16q22.3

Cellular Component: nucleoplasm; transcription factor complex; mitochondrion; intracellular membrane-bound organelle; nucleolus; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; enzyme binding; zinc ion binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; muscle development; regulation of transcription, DNA-dependent; regulation of neuron differentiation; brain development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; cell cycle arrest; positive regulation of myoblast differentiation

Disease: Prostate Cancer