Rabbit XAB2 Polyclonal Antibody | anti-XAB2 antibody

XAB2 Polyclonal Antibody

Cat. Num. AAA2563452

• Gene Names: XAB2; HCNP; HCRN; SYF1; NTC90
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: XAB2; Polyclonal Antibody; XAB2 Polyclonal Antibody; 0610041O14Rik; Adapter protein ATH 55; Adapter protein ATH-55; Ath55; AV025587; Crn related protein kim1; Crn-related protein kim1; DKFZp762C1015; HCNP; HCNP protein; HCRN; KIAA1177; NTC90; PP3898; Pre-mRNA-splicing factor SYF1; Protein HCNP; RNA splicing factor; SYF1; SYF1 homolog; SYF1 pre mRNA splicing factor; Xab2; XPA binding protein 2; XPA-binding protein 2; anti-XAB2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.4mg/mL (varies by lot)
• Sequence Length: 855

• Applicable Applications for anti-XAB2 antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; IHC: 1:25-1:100; ELISA: 1:5000-1:10000
• Immunogen: Synthetic peptide of human XAB2
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of 293T cell lysates using XAB2 Polyclonal Antibody at dilution of 1:250)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using XAB2 Polyclonal Antibody at dilution of 1:25(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using XAB2 Polyclonal Antibody at dilution of 1:25(×200))

Related Product Information for anti-XAB2 antibody

HCNP, also known as XAB2 (Xeroderma pigmentosum group A (XPA) binding protein 2), HCRN, SYF1 or NTC90, is a nuclear protein that participates in transcription, transcription-coupled repair (TCR) and pre-mRNA splicing. It contains fifteen tetratricopeptide repeat motifs and associates with nucleotide excision repair machinery. More specifically, HCNP associates with Cockayne syndrome group A and B proteins (CSA and CSB), RNA Polymerase II (Pol II) and XPA in response to DNA damage and is believed to function in the TCR pathway. HCNP also functions as an essential component of a pre-mRNA splicing complex of the spliceosome (composed of AQR (aquarius), PRP19, CCDC16, HCNP, ISY1 and Cyclophilin E) and is required for proper RNA synthesis in the cell. In addition, HCNP functions as a component of the RAR corepressor complex with RARå and HDAC3 and exhibits an inhibitory effect on ATRA-induced cell differentiation. This suggests that HCNP may function as useful target in cancer therapy.

Product Categories/Family for anti-XAB2 antibody

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 25091548
• NCBI GeneID: 56949
• UniProt Accession #: Q9HCS7
• Molecular Weight: 100 kDa
• NCBI Official Full Name: Pre-mRNA-splicing factor SYF1
• NCBI Official Synonym Full Names: XPA binding protein 2
• NCBI Official Symbol: XAB2
• NCBI Official Synonym Symbols: HCNP; HCRN; SYF1; NTC90
• NCBI Protein Information: pre-mRNA-splicing factor SYF1
• UniProt Protein Name: Pre-mRNA-splicing factor SYF1
• UniProt Gene Name: XAB2
• UniProt Synonym Gene Names: HCNP; KIAA1177; SYF1
• UniProt Entry Name: SYF1_HUMAN

Uniprot Description

XAB2: Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing. Belongs to the crooked-neck family.

Protein type: Spliceosome; RNA splicing

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: nucleoplasm; membrane; nucleus

Molecular Function: protein binding

Biological Process: nuclear mRNA splicing, via spliceosome; blastocyst development; transcription, DNA-dependent; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; DNA repair