Rabbit anti-Human XAB2 Polyclonal Antibody | anti-XAB2 antibody

XAB2, CT (Pre-mRNA-splicing factor SYF1, XPA-binding Protein 2, Protein HCNP, HCNP, KIAA1177, SYF1)

Cat. Num. AAA649957

• Gene Names: XAB2; HCNP; HCRN; SYF1; NTC90
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: XAB2; Polyclonal Antibody; CT (Pre-mRNA-splicing factor SYF1; XPA-binding Protein 2; Protein HCNP; HCNP; KIAA1177; SYF1); Anti -XAB2; anti-XAB2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human XAB2.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS.

• Applicable Applications for anti-XAB2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to the C-terminal of human XAB2 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Kidney (formalin-fixed, paraffin-embedded) stained with XAB2 antibody at 5ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-XAB2 antibody

A novel protein designated XAB2 (XPA-binding protein 2) interacts with XPA, a factor central to both nucleotide excision repair subpathways. Data suggests that XAB2 is a novel component involved in transcription-coupled repair and transcription.

Product Categories/Family for anti-XAB2 antibody

Antibodies; Abs to Splicing Factors

NCBI and Uniprot Product Information

• NCBI GI #: 10566459
• NCBI GeneID: 56949
• UniProt Accession #: Q9HCS7; Q8TET6; Q96HB0; Q96IW0; Q9NRG6; Q9ULP3
• Molecular Weight: 100,010 Da
• NCBI Official Full Name: XAB2
• NCBI Official Synonym Full Names: XPA binding protein 2
• NCBI Official Symbol: XAB2
• NCBI Official Synonym Symbols: HCNP; HCRN; SYF1; NTC90
• NCBI Protein Information: pre-mRNA-splicing factor SYF1; XPA-binding protein 2; crn-related protein kim1; SYF1 pre-mRNA-splicing factor; SYF1 homolog, RNA splicing factor
• UniProt Protein Name: Pre-mRNA-splicing factor SYF1
• UniProt Gene Name: XAB2
• UniProt Synonym Gene Names: HCNP; KIAA1177; SYF1
• UniProt Entry Name: SYF1_HUMAN

Uniprot Description

Function: Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing. Ref.1

Subunit structure: Associates with RNA polymerase II, the TCR-specific proteins CKN1/CSA and ERCC6/CSB, and XPA. Identified in the spliceosome C complex. Ref.1 Ref.8

Subcellular location: Nucleus

By similarity. Note: Detected in the splicing complex carrying pre-mRNA

By similarity.

Sequence similarities: Belongs to the crooked-neck family.Contains 14 HAT repeats.

Sequence caution: The sequence AAF86951.1 differs from that shown. Reason: Frameshift at positions 314, 411, 426, 429 and 468. The sequence AAH08778.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAB84861.1 differs from that shown. Reason: Alternative splicing. Incomplete sequence.