Rabbit WNT7A Polyclonal Antibody | anti-WNT7A antibody

WNT7A (Wingless-type MMTV Integration Site Family Member 7A, Protein Wnt 7a) (MaxLight 550)

Cat. Num. AAA6443487

• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by affinity chromatography.
• Synonyms: WNT7A; Polyclonal Antibody; WNT7A (Wingless-type MMTV Integration Site Family Member 7A; Protein Wnt 7a) (MaxLight 550); anti-WNT7A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes WNT7A. Species Crossreactivity: human, mouse, rat
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

• Applicable Applications for anti-WNT7A antibody: Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: IHC: 1:50-1:200; WB: 1:500-1:2000; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human WNT7A.
• Conjugate: MaxLight550
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-WNT7A antibody

Antibodies; Wnt Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 17505191
• NCBI GeneID: 7476
• NCBI Accession #: NP_004616.2
• NCBI GenBank Nucleotide #: NM_004625.3
• UniProt Accession #: O00755; Q96H90; Q9Y560
• Molecular Weight: 39,005 Da
• NCBI Official Full Name: protein Wnt-7a
• NCBI Official Synonym Full Names: wingless-type MMTV integration site family, member 7A
• NCBI Official Symbol: WNT7A
• NCBI Protein Information: protein Wnt-7a; proto-oncogene Wnt7a protein
• UniProt Protein Name: Protein Wnt-7a
• UniProt Gene Name: WNT7A
• UniProt Entry Name: WNT7A_HUMAN

NCBI Description

This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]

Uniprot Description

WNT7A: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts. Defects in WNT7A are the cause of limb pelvis hypoplasia aplasia syndrome (LPHAS). A syndrome of severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present. Defects in WNT7A are a cause of Fuhrmann syndrome (FUHRS); also known as fibular aplasia or hypoplasia femoral bowing and poly- syn- and oligodactyly. Fuhrmann syndrome is a distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia. Belongs to the Wnt family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: extracellular space; proteinaceous extracellular matrix; cell surface; endoplasmic reticulum lumen; Golgi lumen; plasma membrane; extracellular region

Molecular Function: frizzled binding; cytokine activity; receptor agonist activity; receptor binding

Biological Process: embryonic forelimb morphogenesis; somatic stem cell maintenance; positive regulation of epithelial cell proliferation involved in wound healing; neurotransmitter secretion; positive regulation of transcription, DNA-dependent; cell proliferation in forebrain; positive regulation of JNK cascade; Wnt receptor signaling pathway through beta-catenin; palate development; embryonic hindlimb morphogenesis; response to estradiol stimulus; negative regulation of neurogenesis; neuron differentiation; central nervous system vasculogenesis; regulation of axon diameter; synapse organization and biogenesis; chondrocyte differentiation; somatic stem cell division; satellite cell activation; angiogenesis; fallopian tube development; cartilage condensation; cell fate commitment; embryonic axis specification; satellite cell compartment self-renewal involved in skeletal muscle regeneration; cerebellar granule cell differentiation; asymmetric protein localization; positive regulation of synaptogenesis; stem cell development; dorsal/ventral pattern formation; establishment of cell polarity; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; sex differentiation; negative regulation of apoptosis

Disease: Ulna And Fibula, Absence Of, With Severe Limb Deficiency; Fibular Aplasia Or Hypoplasia, Femoral Bowing And Poly-, Syn-, And Oligodactyly