Western Blot (WB)
(Anti- Wnt7a antibody, Western blottingAll lanes: Anti Wnt7a at 0.5ug/ml)
Wnt7a Polyclonal Antibody | anti-WNT7A antibody
Anti-Wnt7a Antibody
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Western Blot (WB)
(Anti- Wnt7a antibody, Western blottingAll lanes: Anti Wnt7a at 0.5ug/ml)
Western Blot (WB)
(Anti- Wnt7a antibody, Western blottingAll lanes: Anti Wnt7a at 0.5ug/ml)
Immunohistochemistry (IHC)
(Anti- Wnt7a antibody, IHC(P)IHC(P): Mouse Kidney Tissue)
Immunohistochemistry (IHC)
(Anti- Wnt7a antibody, IHC(P)IHC(P): Mouse Kidney Tissue)
Immunohistochemistry (IHC)
(Anti- Wnt7a antibody, IHC(P)IHC(P): Rat Lung Tissue)
Immunohistochemistry (IHC)
(Anti- Wnt7a antibody, IHC(P)IHC(P): Rat Lung Tissue)
Immunohistochemistry (IHC)
(Anti- Wnt7a antibody, IHC(P)IHC(P): Human Endometrial Carcinoma Tissue)
Immunohistochemistry (IHC)
(Anti- Wnt7a antibody, IHC(P)IHC(P): Human Endometrial Carcinoma Tissue)
Background: This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi / Raas Rothschild / Schinzel phocomelia syndromes.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]
Uniprot Description
WNT7A: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts. Defects in WNT7A are the cause of limb pelvis hypoplasia aplasia syndrome (LPHAS). A syndrome of severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present. Defects in WNT7A are a cause of Fuhrmann syndrome (FUHRS); also known as fibular aplasia or hypoplasia femoral bowing and poly- syn- and oligodactyly. Fuhrmann syndrome is a distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia. Belongs to the Wnt family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3p25
Cellular Component: cell surface; cytosol; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; plasma membrane; proteinaceous extracellular matrix
Molecular Function: cytokine activity; frizzled binding; protein binding; receptor agonist activity; receptor binding
Biological Process: angiogenesis; asymmetric protein localization; axonogenesis; cartilage condensation; cell fate commitment; cell proliferation in forebrain; central nervous system vasculogenesis; cerebellar granule cell differentiation; chondrocyte differentiation; dorsal/ventral pattern formation; embryonic axis specification; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; establishment of cell polarity; fallopian tube development; negative regulation of apoptosis; negative regulation of neurogenesis; neurotransmitter secretion; palate development; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of JNK cascade; positive regulation of synaptogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of axon diameter; response to estradiol stimulus; satellite cell activation; satellite cell compartment self-renewal involved in skeletal muscle regeneration; sex differentiation; somatic stem cell division; somatic stem cell maintenance; stem cell development; synaptogenesis; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
Disease: Fibular Aplasia Or Hypoplasia, Femoral Bowing And Poly-, Syn-, And Oligodactyly; Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Research Articles on WNT7A
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Product Notes
The WNT7A wnt7a (Catalog #AAA178195) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-Wnt7a Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Wnt7a can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Western Blot Concentration: 0.1-0.5ug/ml Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml. Researchers should empirically determine the suitability of the WNT7A wnt7a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Wnt7a, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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