Sheep anti-Human VWC2 Polyclonal Antibody | anti-VWC2 antibody
VWC2 (Von Willebrand Factor C Domain Containing 2 Brain-specific Chordin-like Protein, Brorin, UNQ739/PRO1434)
Gene Names
VWC2; UNQ739; PSST739; MGC131845
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
VWC2; Polyclonal Antibody; VWC2 (Von Willebrand Factor C Domain Containing 2 Brain-specific Chordin-like Protein; Brorin; UNQ739/PRO1434); Anti -VWC2 (Von Willebrand Factor C Domain Containing 2 Brain-specific Chordin-like Protein; anti-VWC2 antibody
Host
Sheep
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human Brorin. Species sequence homology: mouse (90%).
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with sterile PBS.
Applicable Applications for anti-VWC2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Dilution: ELISA:0.5-1ug/ml
Western Blot:1ug/ml
Western Blot:1ug/ml
Immunogen
NS0-derived, recombinant human Brorin (aa28-325; Accession #Q2TAL6).
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-VWC2 antibody
Brorin (also VWC2, von Willebrand Factor C domain-containing protein 2) is a secreted, 48-49 kD member of the chordin family of proteins. It is expressed by neurons in multiple sites, and serves to sequester BMP family proteins such as BMP-2 and BMP-6. BMP antagonism is suggested to generate neurons from neural precursor cells at the expense of astrocytes. Human Brorin precursor is 325aa in length. It contains a 27aa signal sequence, one poly-Ala region (aa120-127), and two von Willebrand factor C domains (aa153-212 and 216-274) that likely serve as BMP interaction sites. Over aa28-325, human Brorin shares 90% aa identity with mouse Brorin.
Product Categories/Family for anti-VWC2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
35,282 Da
NCBI Official Full Name
Von Willebrand factor C domain containing 2
NCBI Official Synonym Full Names
von Willebrand factor C domain containing 2
NCBI Official Symbol
VWC2
NCBI Official Synonym Symbols
UNQ739; PSST739; MGC131845
NCBI Protein Information
brorin; OTTHUMP00000159581; brain-specific chordin-like protein; von Willebrand factor C domain-containing protein 2
UniProt Protein Name
Brorin
Protein Family
UniProt Gene Name
VWC2
UniProt Entry Name
VWC2_HUMAN
NCBI Description
This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.
Uniprot Description
PSST739: BMP antagonist which may play a role in neural development. Promotes cell adhesion.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 7p12.2
Cellular Component: extracellular space; basement membrane; synapse; cell junction
Biological Process: positive regulation of neuron differentiation; negative regulation of BMP signaling pathway
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Product Notes
The VWC2 vwc2 (Catalog #AAA631007) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase. The VWC2 (Von Willebrand Factor C Domain Containing 2 Brain-specific Chordin-like Protein, Brorin, UNQ739/PRO1434) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's VWC2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Dilution: ELISA:0.5-1ug/ml Western Blot:1ug/ml. Researchers should empirically determine the suitability of the VWC2 vwc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VWC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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