Rabbit anti-Human, Mouse VPS33B Polyclonal Antibody | anti-VPS33B antibody

VPS33B

Cat. Num. AAA8536830

• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Affinity purification
• Synonyms: VPS33B; Polyclonal Antibody; anti-VPS33B antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Sequence Length: 590

• Applicable Applications for anti-VPS33B antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:1000-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
• Immunogen: Recombinant protein of human VPS33B
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Preparation and Storage: Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-VPS33B antibody

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 574584823
• NCBI GeneID: 26276
• NCBI Accession #: NP_001276077.1
• NCBI GenBank Nucleotide #: NM_001289148.1
• UniProt Accession #: Q9H267; Q96K14; Q9NRP6; Q9NSF3; B3KQF6
• Molecular Weight: 71kDa
• NCBI Official Full Name: vacuolar protein sorting-associated protein 33B isoform 2
• NCBI Official Synonym Full Names: VPS33B, late endosome and lysosome associated
• NCBI Official Symbol: VPS33B
• NCBI Protein Information: vacuolar protein sorting-associated protein 33B
• UniProt Protein Name: Vacuolar protein sorting-associated protein 33B
• Protein Family: Vacuolar protein sorting-associated protein
• UniProt Gene Name: VPS33B
• UniProt Synonym Gene Names: hVPS33B

NCBI Description

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Description

May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages (PubMed:18474358). Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes ().