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Immunohistochemistry (IHC) (Anti-VPS11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Goat VPS11 Polyclonal Antibody | anti-VPS11 antibody

Goat Polyclonal to Human VPS11

Gene Names
VPS11; END1; PEP5; RNF108; hVPS11
Reactivity
Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat
Predicted Reactivity: Xenopus (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry, ELISA
Purity
Immunoaffinity Purified
Synonyms
VPS11; Polyclonal Antibody; Goat Polyclonal to Human VPS11; Anti-VPS11 Antibody (Internal) IHC-plus; END1; HVPS11; PEP5; RING finger protein 108; RNF108; Human VPS11; anti-VPS11 antibody
Ordering
For Research Use Only!
Host
Goat
Reactivity
Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat
Predicted Reactivity: Xenopus (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human VPS11.
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (varies by lot)
Sequence Length
941
Applicable Applications for anti-VPS11 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes
ELISA (1:32000), IHC-P (3.75 ug/ml)
Target Species
Human
Immunogen Description
Synthetic peptide C-HALQEKDTQTKLE from an internal region of human VPS11 (NP_068375.3). Percent identity by BLAST analysis: Human, Gorilla, Marmoset, Mouse, Rat, Hamster, Dog, Bovine, Horse, Pig (100%); Opossum, Xenopus (92%).
Immunogen Type
Synthetic peptide
Immunogen
VPS11 antibody was raised against synthetic peptide C-HALQEKDTQTKLE from an internal region of human VPS11 (NP_068375.3). Percent identity by BLAST analysis: Human, Gorilla, Marmoset, Mouse, Rat, Hamster, Dog, Bovine, Horse, Pig (100%); Opossum, Xenopus (92%); Chicken, Medaka, Zebrafish (85%).
Antigen Modification
Internal
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-VPS11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC) (Anti-VPS11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
107,837 Da
NCBI Official Full Name
vacuolar protein sorting-associated protein 11 homolog isoform 1
NCBI Official Synonym Full Names
vacuolar protein sorting 11 homolog (S. cerevisiae)
NCBI Official Symbol
VPS11
NCBI Official Synonym Symbols
END1; PEP5; RNF108; hVPS11
NCBI Protein Information
vacuolar protein sorting-associated protein 11 homolog; RING finger protein 108
UniProt Protein Name
Vacuolar protein sorting-associated protein 11 homolog
UniProt Gene Name
VPS11
UniProt Synonym Gene Names
RNF108; hVPS11
UniProt Entry Name
VPS11_HUMAN

NCBI Description

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Description

VPS11: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Belongs to the VPS11 family.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: late endosome membrane; lysosome; endocytic vesicle; lysosomal membrane; late endosome; endosome

Molecular Function: protein binding; syntaxin binding; zinc ion binding; nucleotide binding

Biological Process: vesicle-mediated transport; intracellular protein transport

Research Articles on VPS11

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Product Notes

The VPS11 vps11 (Catalog #AAA247701) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat Polyclonal to Human VPS11 reacts with Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat Predicted Reactivity: Xenopus (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's VPS11 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), ELISA (EIA). ELISA (1:32000), IHC-P (3.75 ug/ml). Researchers should empirically determine the suitability of the VPS11 vps11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VPS11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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