Rabbit URM1 Polyclonal Antibody | anti-URM1 antibody

URM1 Rabbit Polyclonal

Cat. Num. AAA7605522

• Gene Names: URM1; C9orf74
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: URM1; Polyclonal Antibody; URM1 Rabbit Polyclonal; anti-URM1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 146

• Applicable Applications for anti-URM1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Ubiquitin related modifier 1 homolog (S. cerevisiae)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver cancer using MBS7605522 (URM1 antibody) at dilution of 1:100)

Western Blot (WB)

(human placenta tissue were subjected to SDS PAGE followed by western blot with MBS7605522 (URM1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 209693464
• NCBI GeneID: 81605
• NCBI Accession #: NP_001129419.1
• NCBI GenBank Nucleotide #: NM_001135947.2
• Molecular Weight: 7,143 Da
• NCBI Official Full Name: ubiquitin-related modifier 1 isoform b
• NCBI Official Synonym Full Names: ubiquitin related modifier 1
• NCBI Official Symbol: URM1
• NCBI Official Synonym Symbols: C9orf74
• NCBI Protein Information: ubiquitin-related modifier 1
• UniProt Protein Name: Ubiquitin-related modifier 1
• Protein Family: Ubiquitin-related modifier
• UniProt Gene Name: URM1
• UniProt Entry Name: URM1_HUMAN

Uniprot Description

URM1: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo. Belongs to the URM1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin-like modifier; Transferase

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: cytosol

Molecular Function: protein binding; sulfurtransferase activity

Biological Process: protein urmylation; tRNA modification; tRNA wobble uridine modification