Rabbit UNC84A Polyclonal Antibody | anti-SUN1 antibody
UNC84A antibody - N-terminal region
Immunohistochemistry (IHC)
(Sample Type :Mouse C2C12 cellsPrimary Antibody Dilution :1:500Secondary Antibody :Goat anti-rabbit-Alexa Fluor 488Secondary Antibody Dilution :1:500Color/Signal Descriptions :UNC84a: Green DAPI: BlueGene Name :UNC84ASubmitted by :Dr. David Razafsky, Washington University in Saint Louis )
Western Blot (WB)
(Host: RabbitTarget Name: SUN1Sample Tissue: Human HCT116 Whole CellAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: SUN1Sample Tissue: Human HCT116Whole CellAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: SUN1Sample Type: Jurkat Whole Cell lysatesAntibody Dilution: 3ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: UNC84ASample Type: Human Adult PlacentaAntibody Dilution: 1.0ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: UNC84ASample Type: Human Fetal LungAntibody Dilution: 1.0ug/ml)
Western Blot (WB)
(WB Suggested Anti-UNC84A Antibody Titration: 0.2-1 ug/mlPositive Control: Jurkat cell lysate)
Target Description: UNC84A is a a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration.This gene is a member of the unc-84 homolog family and encodes a nuclear nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the unc-84 homolog family and encodes a nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2019]
Uniprot Description
SUN1: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non- coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cytoskeletal
Chromosomal Location of Human Ortholog: 7p22.3
Cellular Component: nuclear membrane; intracellular membrane-bound organelle; integral to nuclear inner membrane; nuclear envelope; acrosomal membrane
Molecular Function: protein binding; lamin binding
Biological Process: nuclear membrane organization and biogenesis
