Rabbit anti-Human UNC5A Polyclonal Antibody | anti-UNC5A antibody
Anti-UNC5A Antibody, Rabbit Polyclonal
Gene Names
UNC5A; UNC5H1
Reactivity
Human
Applications
ELISA
Purity
Protein A & Antigen Affinity
Synonyms
UNC5A; Polyclonal Antibody; Anti-UNC5A Antibody; Rabbit Polyclonal; UNC5A/UNC5H1 Antibody; Rabbit PAb; Antigen Affinity Purified; unc-5 homolog A (C. elegans); Anti-UNC5H1 Antibody; anti-UNC5A antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human UNC5A/UNC5H1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-UNC5A antibody
ELISA (EIA)
Application Notes
ELISA: 1:5000-1:10,000
Immunogen
Recombinant Human UNC5A/UNC5H1 Protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Human UNC5A/UNC5H1 (rh UNC5A/UNC5H1). UNC5A/UNC5H1 specific IgG was purified by Human UNC5A/UNC5H1 affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-UNC5A antibody
The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cumulatively downregulated by the unfolding protein response (UPR) at the transcriptional level in vitro and at the translational level both in vitro and in vivo. Also, UNC5A is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
92,932 Da
NCBI Official Full Name
netrin receptor UNC5A
NCBI Official Synonym Full Names
unc-5 homolog A (C. elegans)
NCBI Official Symbol
UNC5A
NCBI Official Synonym Symbols
UNC5H1
NCBI Protein Information
netrin receptor UNC5A; unc-5 homolog 1; netrin receptor Unc5h1; protein unc-5 homolog 1; protein unc-5 homolog A; unc5 (C.elegans homolog) a
UniProt Protein Name
Netrin receptor UNC5A
Protein Family
UniProt Gene Name
UNC5A
UniProt Synonym Gene Names
KIAA1976; UNC5H1
UniProt Entry Name
UNC5A_HUMAN
Uniprot Description
UNC5A: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Belongs to the unc-5 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Cell development/differentiation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component: integral to membrane; intrinsic to plasma membrane; lipid raft; plasma membrane
Biological Process: anterior/posterior axon guidance; apoptosis; axon guidance; neurite development; programmed cell death
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Product Notes
The UNC5A unc5a (Catalog #AAA8106937) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-UNC5A Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's UNC5A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:5000-1:10,000. Researchers should empirically determine the suitability of the UNC5A unc5a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UNC5A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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