Rabbit anti-Rat TRPV2 Polyclonal Antibody | anti-TRPV2 antibody

Anti-TRPV2 (Extracellular) Antibody

Cat. Num. AAA4159147

• Reactivity: Rat
• Applications: Western Blot, Immunoprecipitation
• Purity: Affinity Purified On Immobilized Antigen.
• Synonyms: TRPV2; Polyclonal Antibody; Anti-TRPV2 (Extracellular) Antibody; anti-TRPV2 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Specificity: Mouse 15/16 residues identical.
• Purity/Purification: Affinity Purified On Immobilized Antigen.
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 1ug/ul (varies by lot)

• Applicable Applications for anti-TRPV2 antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: WB: ND7/23 (mouse neuroblastoma x rat DRG neuron hybrid cell line) membrane, RBL (rat basophilic leukemia) lysates and rat brain membrane.; IP: Rat basophilic leukemia lysates (6ug).; ICC: Rat basophilic leukemia live cells (1:100).
• Immunogen: Peptide (C)HQPSLDQPAIPSSKAT (corresponding to residues 413-428 of rat TRPV2(Accession Q9WUD2).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Testing Data

Testing Data

Related Product Information for anti-TRPV2 antibody

TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 The TRP channels have putative six-transmembrane domains (TM) with a pore domain between the fifth and the sixth TM, and all assemble as tetramers. Both the N-and the C-terminus of all TRPs are intracellular.3 According to IUPHAR, the TRP family is comprised of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three additional subfamilies are also considered to belong to the TRP family: the TRPA, TRPML, and TRPP).1-4 The TRPV subfamily consists of six members, TRPV1-6.5 Four members of the TRPV family have been described as a thermosensitive ion channels (TRPV1 to TRPV4). Each channel exhibits distinct thermal activation thresholds ranging from noxious cold (52 degree C).6, 7 Although it shares around 50% homology with TRPV1, TRPV2 is not activated by capsaicin nor by protons. It has a high temperature threshold of ~52 degree C and is considered to play an essential role in the perception of high-intensity noxious heat stimulation.8-10 The TRPV2 is also considered to be a stretch-activated channel and to play a role in skeletal and cardiac muscle degeneration and pain pathway.8 TRPV2 channel is expressed in DRG neurons, different brain region and non-neuronal tissues such as spleen, lung and, intestine and in component of the immune system.5, 11-12