Rabbit anti-Rat ASIC4 Polyclonal Antibody | anti-ASIC4 antibody

Anti-ASIC4 Antibody

Cat. Num. AAA4159175

• Gene Names: ASIC4; ACCN4; BNAC4
• Reactivity: Rat
• Applications: Western Blot
• Purity: Affinity Purified On Immobilized Antigen.
• Synonyms: ASIC4; Polyclonal Antibody; Anti-ASIC4 Antibody; anti-ASIC4 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Specificity: Mouse, human-identical.
• Purity/Purification: Affinity Purified On Immobilized Antigen.
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 1ug/ul (varies by lot)
• Sequence Length: 666

• Applicable Applications for anti-ASIC4 antibody: Western Blot (WB)
• Application Notes: WB: Rat brain, ND7/23 (mouse neuroblastoma x rat DRG neuron hybrid cell line) and dorsal root ganglion (DRG) lysate (1:200-1: 500).
• Immunogen: Peptide CKIKFAEEDAKPKEKEAGDE corresponding to residues 7-26 of rat ASIC4 (Accession Q9QYV9).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Testing Data

Related Product Information for anti-ASIC4 antibody

Acid-sensing ion channels (ASICs) are Na+ channels activated by external protons. ASIC4 is a member of the ASIC family that includes another three members: ASIC1, ASIC2 and ASIC3. The ASIC family is in fact part of a large channel superfamily known as degenerin/epithelial Na+ channels (DEG/ENaC) and share the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N and C termini. The functional ASIC channel is composed of 4 subunits, which can form either a homo or heterotetramer. The subunit composition of the tetrameric channel will determine its biophysical properties such as pH sensitivity, inactivation kinetics and channel pharmacology. In fact, the ASIC4 protein does not appear to function as a proton-gated channel when expressed alone in heterologous systems and therefore a modulatory role for this subunit has been proposed. Expression of the ASIC4 protein has been detected in brain, pituitary gland, spinal cord and inner ear. The functional significance of ASIC4 expression in these tissues still awaits clarification.

NCBI and Uniprot Product Information

• NCBI GI #: 256773228
• NCBI GeneID: 55515
• NCBI GenBank Nucleotide #: NP_061144.3
• UniProt Accession #: Q96FT7
• NCBI Official Full Name: acid-sensing ion channel 4 isoform 1
• NCBI Official Synonym Full Names: acid sensing ion channel subunit family member 4
• NCBI Official Symbol: ASIC4
• NCBI Official Synonym Symbols: ACCN4; BNAC4
• NCBI Protein Information: acid-sensing ion channel 4
• UniProt Protein Name: Acid-sensing ion channel 4
• Protein Family: Acid-sensing ion channel
• UniProt Gene Name: ASIC4
• UniProt Synonym Gene Names: ACCN4; ASIC4
• UniProt Entry Name: ASIC4_HUMAN

NCBI Description

This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]