Western Blot (WB)
(Western blot analysis of anti-LEFTB(C-term) Pab in HL60 cell line lysates (35ug/lane). LEFTB(arrow) was detected using the purified Pab.)
Rabbit anti-Human Lefty (LEFTB) Polyclonal Antibody | anti-LEFTY1 antibody
Lefty (LEFTB) Antibody (C-term)
Western Blot (WB)
(Western blot analysis of anti-LEFTB(C-term) Pab in HL60 cell line lysates (35ug/lane). LEFTB(arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of anti-LEFTB(C-term) Pab in HL60 cell line lysates (35ug/lane). LEFTB(arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with LEFTB antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with LEFTB antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Dvash,T.,Stem Cells 25 (2), 465-472 (2007)
Besser,D.,J. Biol. Chem. 279 (43), 45076-45084 (2004)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008]
Uniprot Description
LEFTY1: Required for left-right axis determination as a regulator of LEFTY2 and NODAL. Belongs to the TGF-beta family.
Protein type: Cytokine; Motility/polarity/chemotaxis; Ligand, receptor tyrosine kinase; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1q42.1
Cellular Component: extracellular space
Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding
Biological Process: regulation of apoptosis; heart morphogenesis; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; cell growth; cell development
Research Articles on LEFTY1
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Product Notes
The LEFTY1 lefty1 (Catalog #AAA9211896) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 283-314. The Lefty (LEFTB) Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Lefty (LEFTB) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the LEFTY1 lefty1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lefty (LEFTB), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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