Testing Data
Rabbit anti-Rat Cav3.2 Polyclonal Antibody | anti-Cav3.2 antibody
Anti-Cav3.2 (a1H, T-Type) Antibody
Reactivity
Rat
Applications
Western Blot
Purity
Affinity Purified On Immobilized Antigen.
Synonyms
Cav3.2; Polyclonal Antibody; Anti-Cav3.2 (a1H; T-Type) Antibody; Ca2+ Channels; anti-Cav3.2 antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Specificity
Mouse, bovine and canis-14/15 residues identical. Human 13/15 residues identical.
Purity/Purification
Affinity Purified On Immobilized Antigen.
Form/Format
Liquid; PBS, pH 7.4 with 0.05% sodium azide.
Concentration
1ug/ul (varies by lot)
Applicable Applications for anti-Cav3.2 antibody
Western Blot (WB)
Application Notes
WB: ND7/23 (mouse neuroblastoma x rat DRG neuron hybrid cell line) lysate (1:200).
Immunogen
Peptide CHVEGPQERARVAHS corresponding to amino acid residues 581-595 of rat Cav3.2. (Accession number Q9EQ60).
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Testing Data
Testing Data
Related Product Information for anti-Cav3.2 antibody
T-type Ca2+ channels play an important role in many cellular processes such as hormone secretion, neurotransmitter release and cell differentiation. T-type channels are also known to participate in the pacemaker activities of heart and neurons including thalamic neurons.1 Three genes encoding T-type Ca2+ channels have been cloned and designated as Cav3.2 (a1H), Cav3.1 (a1G) and Cav3.3 (a1I).1-3 The Cav3.2 (a1H) channel is widely expressed in various tissues, brain, heart, liver and testis. Involvement of Cav3.2 Ca2+ channels in several pathologies has been described. Overexpression of the Cav3.2 channel was described in prostate cancer cells that are associated with more aggressiveness, invasiveness and poor prognosis.4 Several point mutations discovered in the Cav3.2 channel that affect gating of the channel were found to be associated with Childhood Absence Epilepsy.5 One year old mice, deficient in Cav3.2 channel, exhibited severe cardiac pathology, fibrosis, necrosis, lymphocyte infiltration and abnormal coronary function compared to wild-type mice.6 Recently, it has been demonstrated that T-type channels are expressed in DRG neurons and that small and medium-diameter primary afferent neurons in the dorsal horn expresses almost exclusively the Cav3.2 Ca2+channels. This might indicate a possible role for Cav3.2 in nociception.7
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Product Notes
The Cav3.2 (Catalog #AAA4159132) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Cav3.2 (a1H, T-Type) Antibody reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Cav3.2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: ND7/23 (mouse neuroblastoma x rat DRG neuron hybrid cell line) lysate (1:200). Researchers should empirically determine the suitability of the Cav3.2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cav3.2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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