Rabbit anti-Rat TRPC1 Polyclonal Antibody | anti-TRPC1 antibody

Anti-TRPC1 Antibody

Cat. Num. AAA4159140

• Gene Names: TRPC1; TRP1; HTRP-1
• Reactivity: Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified On Immobilized Antigen
• Synonyms: TRPC1; Polyclonal Antibody; Anti-TRPC1 Antibody; anti-TRPC1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Specificity: Mouse, rat, human-identical; rabbit, bovine-14/15 residues identical; Xenopus-11/14 residues identical.
• Purity/Purification: Affinity Purified On Immobilized Antigen
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 1ug/ul (varies by lot)
• Sequence Length: 759

• Applicable Applications for anti-TRPC1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: Rat brain membranes (1:200); IHC: Rat brain sections
• Immunogen: Peptide QLYDK GYTSK EQKDC, corresponding to amino acid residues 557-571 of human TRPC1 (Accession P48995).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Testing Data

Related Product Information for anti-TRPC1 antibody

The Transient Receptor Potential (TRP) superfamily is one of the largest ion channel families and consists of diverse groups of proteins. In mammals about 28 genes encode the TRP ion channel subunits. The mammalian TRP superfamily comprises six subfamilies known as the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPML (mucolipins), TRPP (polycystin) and the TRPA (ANKTM1) ion channels.1-4 The TRPC subfamily consists of seven proteins named TRPC1 to 7, which can be further divided into four subgroups based on their sequence homology and functional similarities: 1.) The TRPC1 2.) TRPC4 and TRPC5 3.) TRPC3, TRPC6, TRPC7 4.) TRPC2.2, 5 They are highly expressed in the central nervous system and to a lesser extent in peripheral tissues. TRPC1 was the first mammalian TRP protein that was reported to form an ion channel.2 It can co-assemble with other TRPC subunits (TRPC3, TRPC4, TRPC5) to form heterotetramers whose properties are distinct from that of their homomeric form. The existence of the TRPC1 homomers has not been established as yet.1-3 The TRPC1, TRPC4 and TRPC5 can be activated either by Ca2+ store depletion or by GPCR stimulation pathways, while TRPC3, TRPC6 and TRPC7 form non-selective cationic channels that are activated by the stimulation of GPCRs. TRPC1, 4 and TRPC5 are assumed to form components of store operated channels in some cell types such as salivary gland cells, endothelial cells and vascular smooth muscle cells.6

NCBI and Uniprot Product Information

• NCBI GI #: 1370119
• NCBI GeneID: 7220
• NCBI Official Full Name: TRPC1 protein
• NCBI Official Synonym Full Names: transient receptor potential cation channel subfamily C member 1
• NCBI Official Symbol: TRPC1
• NCBI Official Synonym Symbols: TRP1; HTRP-1
• NCBI Protein Information: short transient receptor potential channel 1
• Protein Family: Indole-3-glycerol phosphate synthase

NCBI Description

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]