Western Blot (WB)
(Western blot analysis of TREX2 in rat liver tissue lysate with TREX2 antibody at 2.5 μg/mL.)
Rabbit TREX2 Polyclonal Antibody | anti-TREX2 antibody
TREX2 Antibody
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
TREX2 Antibody is affinity chromatography purified via peptide column.
Synonyms
TREX2; Polyclonal Antibody; TREX2 Antibody; Three prime repair exonuclease 2; three prime repair exonuclease 2; anti-TREX2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
This TREX2 antibody will not cross-react with the related protein TREX1.
Purity/Purification
TREX2 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
279
Applicable Applications for anti-TREX2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
TREX2 antibody can be used for detection of TREX2 by Western blot at 2.5 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
Conjugate
Unconjugated
Immunogen
TREX2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TREX2.
Buffer
TREX2 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
TREX2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of TREX2 in rat liver tissue lysate with TREX2 antibody at 2.5 μg/mL.)
Western Blot (WB)
(Western blot analysis of TREX2 in rat liver tissue lysate with TREX2 antibody at 2.5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of TREX2 in human liver tissue with TREX2 antibody at 2.5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of TREX2 in human liver tissue with TREX2 antibody at 2.5 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of TREX2 in Human Liver cells with TREX2 antibody at 20 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of TREX2 in Human Liver cells with TREX2 antibody at 20 μg/mL.)
Related Product Information for anti-TREX2 antibody
TREX2 Antibody: TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
25,922 Da
NCBI Official Full Name
Three prime repair exonuclease 2
NCBI Official Synonym Full Names
three prime repair exonuclease 2
NCBI Official Symbol
TREX2
NCBI Protein Information
three prime repair exonuclease 2; 3'-5' exonuclease TREX2 long form
UniProt Protein Name
Three prime repair exonuclease 2
Protein Family
UniProt Gene Name
TREX2
UniProt Entry Name
TREX2_HUMAN
NCBI Description
This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA polymerase delta. [provided by RefSeq, Nov 2012]
Uniprot Description
TREX2: Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair. Belongs to the exonuclease superfamily. TREX family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Deoxyribonuclease; DNA repair, damage; EC 3.1.11.2
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: nucleus
Molecular Function: protein homodimerization activity; nucleic acid binding; 3'-5'-exodeoxyribonuclease activity; exodeoxyribonuclease III activity; magnesium ion binding
Biological Process: DNA repair; DNA catabolic process, exonucleolytic; DNA metabolic process
Research Articles on TREX2
Similar Products
Product Notes
The TREX2 trex2 (Catalog #AAA150649) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TREX2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TREX2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). TREX2 antibody can be used for detection of TREX2 by Western blot at 2.5 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the TREX2 trex2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TREX2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
