Rabbit TRAX/TSNAX Polyclonal Antibody | anti-TSNAX antibody

Anti-TRAX/TSNAX Antibody, Rabbit Polyclonal

Cat. Num. AAA8101266

• Gene Names: TSNAX; TRAX
• Reactivity: Human; Predicted to React with: Cynomolgus (Species predicted to react based on 100% sequence homology)
• Applications: Immunohistochemistry, Immunocytochemistry, Immunofluorescence
• Purity: Protein A & Antigen Affinity
• Synonyms: TRAX/TSNAX; Polyclonal Antibody; Anti-TRAX/TSNAX Antibody; Rabbit Polyclonal; TSNAX Antibody; Rabbit PAb; Antigen Affinity Purified; translin-associated factor X; Anti-TRAX Antibody; anti-TSNAX antibody

• Host: Rabbit
• Reactivity: Human; Predicted to React with: Cynomolgus (Species predicted to react based on 100% sequence homology)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human TRAX/TSNAX
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-TSNAX antibody: Immunohistochemistry-Paraffin (IHC-P), Immunocytochemistry (ICC), Immunofluorescence (IF)
• Application Notes: IHC-P: 1:500-1:2000; ICC/IF: 1:200-1:1000
• Immunogen: A synthetic peptide corresponding to the center region of the Human TSNAX
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human TSNAX, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human TSNAX in human testis with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Immunofluorescence (IF)

(Immunofluorescence staining of TSNAX in HeLa cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-human TSNAX polyclonal antibody (1:1000) at 4 degree C overnight. Then cells were stained with the Alexa Fluor488-conjugated Goat Anti-rabbit IgG secondary antibody (green).Positive staining was localized to cytoplasm and nucleus.)

Related Product Information for anti-TSNAX antibody

Dysregulation of TSNAX influences steroidogenic factor-1-stimulated transcription on the StAR promoter, altering progesterone actions, implying the association with cancer. The translin-associated factor X gene (TSNAX)/disrupted-in-schizophrenia-1 gene (DISC1) has been associated with psychiatric disorders, including schizophrenia, MDD and bipolar disorder. TSNAX is located immediately upstream of DISC1 and has been shown to undergo intergenic splicing with DISC1.

NCBI and Uniprot Product Information

• NCBI GI #: 20302159
• NCBI GeneID: 7257
• NCBI Accession #: NP_005990.1
• NCBI GenBank Nucleotide #: NM_005999
• UniProt Accession #: Q99598; B1APC6
• Molecular Weight: 33,112 Da
• NCBI Official Full Name: Homo sapiens translin-associated factor X (TSNAX), mRNA
• NCBI Official Synonym Full Names: translin-associated factor X
• NCBI Official Symbol: TSNAX
• NCBI Official Synonym Symbols: TRAX
• NCBI Protein Information: translin-associated protein X; translin-like protein
• UniProt Protein Name: Translin-associated protein X
• Protein Family: Translin-associated protein
• UniProt Gene Name: TSNAX
• UniProt Synonym Gene Names: TRAX
• UniProt Entry Name: TSNAX_HUMAN

NCBI Description

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]

Uniprot Description

TSNAX: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. Belongs to the translin family.

Protein type: Nuclear receptor co-regulator; DNA-binding

Chromosomal Location of Human Ortholog: 1q42.1

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus

Molecular Function: endoribonuclease activity; DNA binding; sequence-specific DNA binding; metal ion binding; single-stranded DNA binding; protein transporter activity

Biological Process: protein transport; multicellular organismal development; gene expression; spermatogenesis; cell differentiation