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Nuclear Receptor Coactivator 3 Recombinant Protein | NCOA3 recombinant protein
Recombinant Nuclear Receptor Coactivator 3 (NCOA3)
Source: Prokaryotic expression
MSGLGESSLD PLATESRKRK LPCDAPGQGL VYSGEKWRRE QESKYIEELA ELISANLSDI DNFNVKPDKC AILKETVRQI RQIKEQGKTI SSDDDVQKAD VSSTGQGVID KDSLGPLLLQ ALDGFLFVVN RDGNIVFVSE NVTQYLQYKQ EDLVNTSVYS ILHEQDRKDF LNTYQNPQLM EFLGRMRTRD KKAIHLIRML MKTHDILEDT NASPETRQRY ETMQCFALSQ PRAMLEEGED LQCCMICVAR RVTTDRPFPS SPESFITR
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
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NCBI and Uniprot Product Information
Uniprot Description
SRC-3: a histone acetyltransferase and nuclear receptor coactivator. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Activity is enhanced by various hormones and TNF. Acetylation by CREBBP may suppress coactivation of target genes by disrupting its association with nuclear receptors. Frequently amplified or overexpressed in breast and ovarian cancers. Five alternatively spliced isoforms have been described.
Protein type: EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Acetyltransferase; Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; Golgi apparatus; perinuclear region of cytoplasm; cytoplasm; nucleus
Molecular Function: ligand-dependent nuclear receptor binding; protein dimerization activity; peroxisome proliferator activated receptor binding; transcription coactivator activity; protein N-terminus binding; transferase activity; signal transducer activity; histone acetyltransferase activity; androgen receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; protein complex binding; transferase activity, transferring acyl groups; estrogen receptor binding; chromatin binding; nuclear hormone receptor binding
Biological Process: developmental growth; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; multicellular organism growth; positive regulation of steroid hormone receptor signaling pathway; positive regulation of estrogen receptor signaling pathway; vagina development; signal transduction; positive regulation of cell growth; cellular response to hormone stimulus; regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; histone acetylation; negative regulation of apoptosis; positive regulation of keratinocyte differentiation
Research Articles on NCOA3
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Product Notes
The NCOA3 ncoa3 (Catalog #AAA2030870) is a Recombinant Protein produced from Host: E Coli Source: Prokaryotic expression and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Nuclear Receptor Coactivator 3 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the NCOA3 ncoa3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.MSGLGESSL D PLATESRKRK LPCDAPGQGL VYSGEKWRRE QESKYIEELA ELISANLSDI DNFNVKPDKC AILKETVRQI RQIKEQGKTI SSDDDVQKAD VSSTGQGVID KDSLGPLLLQ ALDGFLFVVN RDGNIVFVSE NVTQYLQYKQ EDLVNTSVYS ILHEQDRKDF LNTYQNPQLM EFLGRMRTRD KKAIHLIRML MKTHDILEDT NASPETRQRY ETMQCFALSQ PRAMLEEGED LQCCMICVAR RVTTDRPFPS SPESFITR. It is sometimes possible for the material contained within the vial of "Nuclear Receptor Coactivator 3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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