Rabbit anti-Human TOM1L1 Polyclonal Antibody | anti-TOM1L1 antibody

TOM1L1, CT (TOM1-like Protein 1, Src-activating and Signaling Molecule Protein, Target of Myb-like Protein 1, SRCASM)

Cat. Num. AAA6010982

• Gene Names: TOM1L1; SRCASM; OK/KNS-CL.3
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: TOM1L1; Polyclonal Antibody; CT (TOM1-like Protein 1; Src-activating and Signaling Molecule Protein; Target of Myb-like Protein 1; SRCASM); Anti -TOM1L1; anti-TOM1L1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human TOM1L1.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.01% sodium azide, 50% glycerol.

• Applicable Applications for anti-TOM1L1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: ELISA: 1ug/ml; Western Blot: 1ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 20ug/ml
• Immunogen: Synthetic peptide corresponding to human TOM1L1 at C-terminal (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Kidney (formalin-fixed, paraffin-embedded) stained with TOM1L1 antibody at 20ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-TOM1L1 antibody

TOM1L1, or Tom1-like1, is a member of the TOM1 family which contain a GAT domain and VHS domain. The GAT domain has been shown to bind ubiquitin while the VHS domain might function as a multipurpose docking adapter that localizes proteins to the membrane. These domains suggest that the TOM1 family may play a role as an intermediary between signaling and degradative pathways.

Product Categories/Family for anti-TOM1L1 antibody

Antibodies; Abs to Adapter Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 191252812
• NCBI GeneID: 10040
• NCBI Accession #: NP_005477.2
• NCBI GenBank Nucleotide #: NM_005486.2
• UniProt Accession #: O75674; Q53G06
• Molecular Weight: 52,989 Da
• NCBI Official Full Name: TOM1-like protein 1
• NCBI Official Synonym Full Names: target of myb1 (chicken)-like 1
• NCBI Official Symbol: TOM1L1
• NCBI Official Synonym Symbols: SRCASM; OK/KNS-CL.3
• NCBI Protein Information: TOM1-like protein 1; target of myb1-like 1; target of myb 1-like 1; target of Myb-like protein 1; Src activating and signaling molecule; src-activating and signaling molecule protein
• UniProt Protein Name: TOM1-like protein 1
• Protein Family: TOM1-like protein
• UniProt Gene Name: TOM1L1
• UniProt Synonym Gene Names: SRCASM
• UniProt Entry Name: TM1L1_HUMAN

Uniprot Description

Srcasm: an adapter protein that is a src-family kinase substrate. When phosphorylated, it binds src-family kinases and targets them for lysosomal-dependent degradation. EGF triggers a transient association of phosphorylated Srcasm with EGFR via Grb2 and Shc initiating the endocytosis of the ligand-receptor complex. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. Involved in multivesicular body (MVB) formation, viral egress from the cell, and cytokinesis. Belongs to the TOM1 family. Interacts with FYN, GRB2 and PIK3R1 when phosphorylated. The PTAP sequence in the GAT domain and the PSAP sequence in the C-terminal region are responsible for its interaction with the UEV domain of Tsg101, a component of the ESCRT-1 complex. Localizes to the multivesicular body (MVB) that is involved in targeting endosomal proteins for lysosomal degradation.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: Golgi stack; lysosome; cytoplasm; endosome membrane; cytosol; endosome

Molecular Function: protein binding; ubiquitin binding; clathrin binding; SH3 domain binding; protein kinase activator activity; protein kinase binding

Biological Process: intracellular protein transport; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; negative regulation of mitosis; activation of protein kinase activity; signal transduction; positive regulation of protein amino acid autophosphorylation