Rabbit Toll-like Receptor 6 (TLR6) Polyclonal Antibody | anti-TLR6 antibody

Toll-like Receptor 6 (TLR6) Polyclonal Antibody

Cat. Num. AAA194449

• Gene Names: TLR6; CD286
• Applications: Western Blot, Immunohistochemistry
• Synonyms: Toll-like Receptor 6 (TLR6); Polyclonal Antibody; Toll-like Receptor 6 (TLR6) Polyclonal Antibody; anti-TLR6 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Toll-like Receptor 6 (TLR6) [Rabbit polyclonal antibody recognizes human TLR6]; This antibody recognizes human TLR6.
• Form/Format: 50ug purified by antigen affinity chromatography in PBS containing 0.02% sodium azide.
• Sequence Length: 796

• Applicable Applications for anti-TLR6 antibody: Western Blot, Immunohistochemistry
• Application Notes: Western Blotting: use at 0.5-1ug/ml. A band of approximately 91 kDa is detected.; Immunohistochemistry: formalin-fixed, paraffin-embedded tissues, use at 5ug/ml.
• Antigen: Synthetic peptide corresponding to 13 amino acids near the center of human TLR6.
• Preservatives: 0.02% sodium azide
• Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: Store at 4 degree C (short-term) or -70 degree C (long-term).

Immunohistochemistry

Related Product Information for anti-TLR6 antibody

TLR6 is a 796 aa protein containing 20 N-terminal leucine-rich repeat motifs (LRRs) with a molecular weight of 91 kDa. TLR6 is most closely related to TLR1, TLR10, and TLR2 with 68%, 46%, and 31% overall aa sequence identity, respectively. In vivo, TLR6 transcript is observed in thymus, spleen, and lung. TLR6 mRNA expression is highest in B cells and monocytes. TLR6 forms a heterodimer with TLR2. Like TLR1, TLR6 is thought to specify or enhance TLR2 and contribute to its signaling capabilities through heterodimerization.

Product Categories/Family for anti-TLR6 antibody

Neuroscience and Signal Transduction Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 164708005
• NCBI GeneID: 10333
• UniProt Accession #: B6CH35; B3Y640; B6RFS4; B6RFS5; Q2NKL3; Q9Y2C9
• NCBI Official Full Name: toll-like receptor 6
• NCBI Official Synonym Full Names: toll-like receptor 6
• NCBI Official Symbol: TLR6
• NCBI Official Synonym Symbols: CD286
• NCBI Protein Information: toll-like receptor 6; OTTHUMP00000218187
• UniProt Protein Name: Toll-like receptor 6
• UniProt Gene Name: TLR6
• UniProt Entry Name: TLR6_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.

Uniprot Description

TLR6: Participates in the innate immune response to Gram- positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: phagocytic vesicle membrane; integral to plasma membrane; plasma membrane

Molecular Function: transmembrane receptor activity; protein heterodimerization activity; receptor activity; diacylated lipoprotein binding

Biological Process: positive regulation of JNK activity; T-helper 1 type immune response; regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; detection of diacylated bacterial lipoprotein; positive regulation of interleukin-6 biosynthetic process; activation of NF-kappaB-inducing kinase; signal transduction; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; defense response to bacterium; toll-like receptor 6 signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; inflammatory response; toll-like receptor 4 signaling pathway