Rabbit anti-Human, Mouse Toll-like receptor 6 (TLR6) Polyclonal Antibody | anti-TLR6 antibody

Toll-like receptor 6 (TLR6) (NT)

Cat. Num. AAA395476

• Gene Names: TLR6; CD286
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunocytochemistry
• Purity: Antigen Immunoaffiinity Purification
• Synonyms: Toll-like receptor 6 (TLR6); Polyclonal Antibody; Toll-like receptor 6 (TLR6) (NT); TLR6 (IN): Toll-like receptor 6; CD286 antigen; anti-TLR6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Immunoaffiinity Purification
• Form/Format: Provided as solution in phosphate buffered saline with 0.02% sodium azide
• Sequence Length: 796

• Applicable Applications for anti-TLR6 antibody: Western Blot (WB), Immunocytochemistry (ICC)
• Immunogen: Rabbit polyclonal TLR6 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR6.
• Positive Control: Positive Control Jurkat cell Lysate. Located in the membrane, TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.7
• Preparation and Storage: Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Western Blot/Blotting

(Western blot analysis of TLR6 in Jurkat cell lysate with TLR6 antibody at (A) 0.5, (B) 1 and (C) 2 g/ml.)

Related Product Information for anti-TLR6 antibody

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify (4). Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan (5). Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses (6).

Product Categories/Family for anti-TLR6 antibody

Polyclonal Antibody; Cytokines

NCBI and Uniprot Product Information

• NCBI GI #: 20143971
• NCBI GeneID: 10333
• NCBI Accession #: NP_006059.2
• NCBI GenBank Nucleotide #: NM_006068.4
• UniProt Accession #: Q9Y2C9; B3Y640; B6CH35; B6RFS4; B6RFS5
• Molecular Weight: 96 kD
• NCBI Official Full Name: toll-like receptor 6
• NCBI Official Synonym Full Names: toll-like receptor 6
• NCBI Official Symbol: TLR6
• NCBI Official Synonym Symbols: CD286
• NCBI Protein Information: toll-like receptor 6
• UniProt Protein Name: Toll-like receptor 6
• UniProt Gene Name: TLR6
• UniProt Entry Name: TLR6_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]

Uniprot Description

Function: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. Ref.6

Subunit structure: Binds MYD88 via their respective TIR domains. Heterodimer with TLR2 via their respective extracellular domains

By similarity.

Subcellular location: Cell membrane; Single-pass type I membrane protein

By similarity. Cytoplasmic vesicle › phagosome membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

Sequence similarities: Belongs to the Toll-like receptor family.Contains 19 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 TIR domain.