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Western Blot (WB) (TMPRSS6 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TMPRSS6 antibody detected the TMPRSS6 protein (arrow).)

Rabbit anti-Human TMPRSS6 Polyclonal Antibody | anti-TMPRSS6 antibody

TMPRSS6, NT (TMPRSS6, Transmembrane protease serine 6, Matriptase-2)

Gene Names
TMPRSS6; IRIDA
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity Purified
Purified by Protein A affinity chromatography.
Synonyms
TMPRSS6; Polyclonal Antibody; NT (TMPRSS6; Transmembrane protease serine 6; Matriptase-2); Anti -TMPRSS6; anti-TMPRSS6 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Human
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Applicable Applications for anti-TMPRSS6 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunogen
TMPRSS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-114 amino acids from the N-terminal region of human TMPRSS6.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TMPRSS6 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TMPRSS6 antibody detected the TMPRSS6 protein (arrow).)

Western Blot (WB) (TMPRSS6 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TMPRSS6 antibody detected the TMPRSS6 protein (arrow).)
Related Product Information for anti-TMPRSS6 antibody
The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
Product Categories/Family for anti-TMPRSS6 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
90,000 Da
NCBI Official Full Name
transmembrane protease serine 6
NCBI Official Synonym Full Names
transmembrane protease, serine 6
NCBI Official Symbol
TMPRSS6
NCBI Official Synonym Symbols
IRIDA
NCBI Protein Information
transmembrane protease serine 6; matriptase-2; type II transmembrane serine protease 6; membrane-bound mosaic serine proteinase matriptase-2
UniProt Protein Name
Transmembrane protease serine 6
UniProt Gene Name
TMPRSS6
UniProt Entry Name
TMPS6_HUMAN

NCBI Description

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Plays a role in the regulation of iron homeostasis, a process involving HAMP. Required to sense iron deficiency and suppress activation of the HAMP promoter. Ref.1 Ref.15

Subunit structure: Interacts with HFE2. Ref.10 Ref.13

Subcellular location: Cell membrane; Single-pass type II membrane protein Ref.1 Ref.12.

Tissue specificity: Liver specific. Ref.1

Domain: Cytoplasmic domain mediates HAMP suppression via proximal promoter element(s)

By similarity.

Post-translational modification: The single-chain zymogen undergoes proteolytic processing. This results in TMPRSS6 shedding from the cell surface and conversion into an activated two-chains form. The process involves a trans-activation mechanism that requires TMPRSS6 oligomerization.

Involvement in disease: Iron-refractory iron deficiency anemia (IRIDA) [MIM:206200]: Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.Note: The disease is caused by mutations affecting the gene represented in this entry. Mutations leading to abrogation of TMPRSS6 activity are associated with IRIDA due to elevated levels of hepcidin, a negative regulator of plasma iron pool (Ref.19). Ref.9 Ref.10 Ref.11 Ref.13 Ref.15 Ref.16 Ref.17 Ref.19 Ref.21 Ref.22

Sequence similarities: Belongs to the peptidase S1 family.Contains 2 CUB domains.Contains 3 LDL-receptor class A domains.Contains 1 peptidase S1 domain.

Research Articles on TMPRSS6

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Product Notes

The TMPRSS6 tmprss6 (Catalog #AAA648381) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TMPRSS6, NT (TMPRSS6, Transmembrane protease serine 6, Matriptase-2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TMPRSS6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the TMPRSS6 tmprss6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TMPRSS6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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