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Western Blot (WB) (Western blot analysis of TM4SF1 in human lung tissue lysate with TM4SF1 antibody at (A) 0.5 and (B) 1 ug/mL.)

Rabbit TM4SF1 Polyclonal Antibody | anti-TM4SF1 antibody

TM4SF1 Antibody

Gene Names
TM4SF1; L6; H-L6; M3S1; TAAL6
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column
Synonyms
TM4SF1; Polyclonal Antibody; TM4SF1 Antibody; Transmembrane 4 L6 family member 1; L6; H-L6; M3S1; TAAL6; anti-TM4SF1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
At least three isoforms of TM4SF1 are known to exist; this antibody will recognize only the two largest isoforms. TM4SF1 antibody is predicted to not cross-react with other tetraspanin proteins.
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
202
Applicable Applications for anti-TM4SF1 antibody
ELISA (EIA), Western Blot (WB)
Immunogen Type
Peptide
Immunogen Description
Raised against an 18 amino acid peptide near the amino terminus of human TM4SF1.
Target Name
TM4SF1
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of TM4SF1 in human lung tissue lysate with TM4SF1 antibody at (A) 0.5 and (B) 1 ug/mL.)

Western Blot (WB) (Western blot analysis of TM4SF1 in human lung tissue lysate with TM4SF1 antibody at (A) 0.5 and (B) 1 ug/mL.)
Related Product Information for anti-TM4SF1 antibody
TM4SF1 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains and mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4SF1 is a cell surface antigen and is highly expressed in the vascular endothelium of several human cancers. Knockdown experiments of TM4SF1 prevented filopodia formation, inhibited cell mobility, blocked cytokinesis, and inhibited maturation of VEGF-A-induced angiogenesis, suggesting that TM4SF1 may be an attractive target for anti-angiogenesis therapy.
Product Categories/Family for anti-TM4SF1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
21,632 Da
NCBI Official Full Name
transmembrane 4 L6 family member 1
NCBI Official Synonym Full Names
transmembrane 4 L six family member 1
NCBI Official Symbol
TM4SF1
NCBI Official Synonym Symbols
L6; H-L6; M3S1; TAAL6
NCBI Protein Information
transmembrane 4 L6 family member 1
UniProt Protein Name
Transmembrane 4 L6 family member 1
Protein Family
UniProt Gene Name
TM4SF1
UniProt Synonym Gene Names
M3S1; TAAL6
UniProt Entry Name
T4S1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]

Uniprot Description

TM4SF1: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins apparently mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular. Present in high molecular weight complexes in tumor cells.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q21-q25

Cellular Component: integral to plasma membrane

Research Articles on TM4SF1

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Product Notes

The TM4SF1 tm4sf1 (Catalog #AAA9401702) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TM4SF1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TM4SF1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the TM4SF1 tm4sf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TM4SF1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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