Rabbit anti-Human TM4SF1 Polyclonal Antibody | anti-TM4SF1 antibody

TM4SF1, NT (TM4SF1, M3S1, TAAL6, Transmembrane 4 L6 family member 1, Membrane component chromosome 3 surface marker 1, Tumor-associated antigen L6)

Cat. Num. AAA647982

• Gene Names: TM4SF1; L6; H-L6; M3S1; TAAL6
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: TM4SF1; Polyclonal Antibody; NT (TM4SF1; M3S1; TAAL6; Transmembrane 4 L6 family member 1; Membrane component chromosome 3 surface marker 1; Tumor-associated antigen L6); Anti -TM4SF1; anti-TM4SF1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human TM4SF1. Predicted to not cross-react with other tetraspanin proteins.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-TM4SF1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Western Blot: 0.5-1ug/ml; Immunohistochemistry (Paraffin): 5ug/ml
• Immunogen: Synthetic peptide corresponding to human TM4SF1 at N-Terminal.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(TM4SF1 (5ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human uterus, vessels, followed by biotinylated goat, rabbit IgG, alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-TM4SF1 antibody

TM4SF1 is a cell-surface antigen highly expressed in lung, breast, colon, and ovarian carcinomas. It could be used as therapeutic target for monoclonal antibodies in the treatment of these cancers.

Product Categories/Family for anti-TM4SF1 antibody

Antibodies; Abs to Transmembrane Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 21265101
• NCBI GeneID: 4071
• NCBI Accession #: NP_055035.1
• NCBI GenBank Nucleotide #: NM_014220.2
• UniProt Accession #: P30408; Q6IB51
• Molecular Weight: 21,632 Da
• NCBI Official Full Name: transmembrane 4 L6 family member 1
• NCBI Official Synonym Full Names: transmembrane 4 L six family member 1
• NCBI Official Symbol: TM4SF1
• NCBI Official Synonym Symbols: L6; H-L6; M3S1; TAAL6
• NCBI Protein Information: transmembrane 4 L6 family member 1; tumor-associated antigen L6; transmembrane 4 superfamily member 1; membrane component chromosome 3 surface marker 1; membrane component, chromosome 3, surface marker 1
• UniProt Protein Name: Transmembrane 4 L6 family member 1
• Protein Family: Transmembrane 4 L6 family
• UniProt Gene Name: TM4SF1
• UniProt Synonym Gene Names: M3S1; TAAL6
• UniProt Entry Name: T4S1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]

Uniprot Description

Subunit structure: Present in high molecular weight complexes in tumor cells.

Subcellular location: Membrane; Multi-pass membrane protein.

Tissue specificity: Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.

Sequence similarities: Belongs to the L6 tetraspanin family.