anti-Mouse TLR11 Polyclonal Antibody | anti-TLR11 antibody

Anti - TLR11 (Toll Like Receptor 11)

Cat. Num. AAA614620

• Gene Names: Tlr11; Gm287; MGC129352; MGC129353
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Ion Exchange chromatography.
• Synonyms: TLR11; Polyclonal Antibody; Anti - TLR11 (Toll Like Receptor 11); TLR11 (Toll Like Receptor 11); anti-TLR11 antibody

• Host: Host: Rabbit; Source: Mouse
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse TLR11.
• Purity/Purification: Purified by Ion Exchange chromatography.
• Form/Format: Highly Purified; Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
• Concentration: ~1mg/ml (varies by lot)
• Sequence Length: 926

• Applicable Applications for anti-TLR11 antibody: Western Blot
• Application Notes: Can be used for detection of TLR11 by Western blot at 0.5-2ug/ml.
• Immunogen: Raised against a peptide corresponding to 16 amino acids near the middle of mouse TLR11 (GenBank accession no. NP_991388)
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20 degree C or colder. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of TLR11 in RAW264.7 cell lysates with MBS614620 at (A) 0.5, (B) 1, and (C) 2 ug/ml.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of MBS614620.)

Related Product Information for anti-TLR11 antibody

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1-3). These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (4,5). TLR11 is one of three mouse TLRs that lack a human ortholog (6). It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system (7).

Product Categories/Family for anti-TLR11 antibody

Abs to Toll Like Receptors (TLR)

References

• 1. Vogel SN, et al Mol. Interv. 2003; 3:466-77.
• 2. Takeda K, et al Annu. Rev. Immunol. 2003; 21:335-76.
• 3. Janeway CA Jr. and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
• 4. O'Neill LAJ,et al Trends in Imm. 2003; 24:286-9.
• 5. McGettrick AF et al Mol Imm. 2004; 41:577-82.
• 6. Heil F, et al. Eur. J. Immunol. 2003; 33:2987-2997.
• 7. Heil F, et al Science 2004; 303:1526-9.
• 8. Jurk M, et al Nat. Immunol. 2002; 3:499.

NCBI and Uniprot Product Information

• NCBI GI #: 45429992
• NCBI GeneID: 239081
• NCBI Accession #: NP_991388.1
• NCBI GenBank Nucleotide #: NM_205819.2
• UniProt Accession #: Q32ME8; Q6R5P0
• Molecular Weight: 105,827 Da
• NCBI Official Full Name: toll-like receptor 11
• NCBI Official Synonym Full Names: toll-like receptor 11
• NCBI Official Symbol: Tlr11
• NCBI Official Synonym Symbols: Gm287; MGC129352; MGC129353
• NCBI Protein Information: toll-like receptor 11
• UniProt Protein Name: Toll-like receptor 11
• Protein Family: Toll-like receptor
• UniProt Gene Name: Tlr11
• UniProt Entry Name: Q32ME8_MOUSE