Rabbit anti-Mouse TLR11 Polyclonal Antibody | anti-Tlr11 antibody

TLR11 Antibody

Cat. Num. AAA150758

• Gene Names: Tlr11; Gm287
• Reactivity: Mouse
• Applications: ELISA, Western Blot, Immunocytochemistry, Immunofluorescence
• Purity: TLR11 Antibody is Ion exchange chromatography purified.
• Synonyms: TLR11; Polyclonal Antibody; TLR11 Antibody; Gm287; Toll-like receptor 11; toll-like receptor 11; anti-Tlr11 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: TLR11 Antibody is Ion exchange chromatography purified.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 926

• Applicable Applications for anti-Tlr11 antibody: ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
• Application Notes: TLR11 antibody polyclonal antibody can be used for detection of TLR11 by Western blot at 0.5 to 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 10 mug/mL.
• Conjugate: Unconjugated
• Immunogen: TLR11 antibody was raised against a peptide corresponding to 16 amino acids between the middle and carboxy terminus of mouse TLR11.
• Buffer: TLR11 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TLR11 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of TLR11 in RAW264.7 cell lysates with TLR11 antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.)

Immunocytochemistry (IHC)

(Immunocytochemistry of TLR11 in RAW264.7 cells with TLR11 antibody at 10 μg/mL)

Immunofluorescence (IF)

(Immunofluorescence of TLR11 in Raw264 cells with TLR11 antibody at 10 μg/mL.)

Related Product Information for anti-Tlr11 antibody

TLR11 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR11 is one of three mouse TLRs that lack a human ortholog. It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system.

NCBI and Uniprot Product Information

• NCBI GI #: 45429992
• NCBI GeneID: 239081
• NCBI Accession #: NP_991388
• NCBI GenBank Nucleotide #: NM_205819.2
• UniProt Accession #: Q6R5P0
• Molecular Weight: 105,873 Da
• NCBI Official Full Name: toll-like receptor 11
• NCBI Official Synonym Full Names: toll-like receptor 11
• NCBI Official Symbol: Tlr11
• NCBI Official Synonym Symbols: Gm287
• NCBI Protein Information: toll-like receptor 11
• UniProt Protein Name: Toll-like receptor 11
• Protein Family: Toll-like receptor
• UniProt Gene Name: Tlr11
• UniProt Synonym Gene Names: Gm287
• UniProt Entry Name: TLR11_MOUSE

Uniprot Description

Tlr11: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Cellular Component: membrane; integral to membrane

Molecular Function: protein binding; transmembrane receptor activity

Biological Process: MyD88-dependent toll-like receptor signaling pathway; regulation of cytokine secretion; response to bacterium; immune system process; innate immune response; inflammatory response; signal transduction; toll-like receptor 11 signaling pathway; positive regulation of inflammatory response