Rabbit TLR11 Polyclonal Antibody | anti-TLR11 antibody

RABBIT ANTI MOUSE TLR11 (C-TERMINAL)

Cat. Num. AAA223645

• Gene Names: Tlr11; Gm287
• Applications: Immunohistochemistry, Western Blot
• Synonyms: TLR11; Polyclonal Antibody; RABBIT ANTI MOUSE TLR11 (C-TERMINAL); anti-TLR11 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1.0mg/ml (varies by lot)
• Sequence Length: 931

• Applicable Applications for anti-TLR11 antibody: Immunohistology Frozen, Western Blot (WB)
• Application Notes: Immunohistology - Frozen: Maximum Dilution: 10ug/ml;; Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 1.0ug/ml
• Perservative Stabilisers: 0.02% Sodium Azide (NaN3)
• Immunogen: Synthetic peptide corresponding to a 15 amino acid sequence near the carboxy terminus of mouse TLR11.; Buffer Solution
• Antiserum Preparation: Antisera to mouse TLR11 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.
• Target Species: Mouse
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Testing Data #1

(Western blot analysis of whole cell lysate from RAW264.7 mouse monocyte/ macrophage cells probed with Rabbit anti Mouse TLR11 (MBS223645))

Testing Data #2

(Immunocytochemical staining of RAW264.7 cells with Rabbit anti Mouse TLR11 (MBS223645))

Related Product Information for anti-TLR11 antibody

Rabbit anti Mouse TLR11 (C-Terminal) antibody recognizes the C-Terminal of mouse Toll-like receptor 11 (TLR11). TLR11 is principally expressed in macrophages and liver, and epithelial cells of the kidney and bladder. Mouse TLR11 is reported to recognize uropathogenic bacteria, and to activate appropriate host defense genes as part of the innate immune response to microbial infection.

NCBI and Uniprot Product Information

• NCBI GI #: 408684413
• NCBI GeneID: 239081
• NCBI Accession #: NP_991388.2
• NCBI GenBank Nucleotide #: NM_205819.3
• UniProt Accession #: Q6R5P0
• Molecular Weight: 105,873 Da
• NCBI Official Full Name: toll-like receptor 11
• NCBI Official Synonym Full Names: toll-like receptor 11
• NCBI Official Symbol: Tlr11
• NCBI Official Synonym Symbols: Gm287
• NCBI Protein Information: toll-like receptor 11
• UniProt Protein Name: Toll-like receptor 11
• Protein Family: Toll-like receptor
• UniProt Gene Name: Tlr11
• UniProt Synonym Gene Names: Gm287
• UniProt Entry Name: TLR11_MOUSE

Uniprot Description

Tlr11: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Cellular Component: membrane; integral to membrane

Molecular Function: protein binding; transmembrane receptor activity

Biological Process: MyD88-dependent toll-like receptor signaling pathway; regulation of cytokine secretion; response to bacterium; immune system process; innate immune response; inflammatory response; signal transduction; toll-like receptor 11 signaling pathway; positive regulation of inflammatory response