Rabbit TIMP-4 Polyclonal Antibody | anti-TIMP-4 antibody
Rabbit anti TIMP-4 Polyclonal Antibody
Reactivity
Human, Rat, Mouse, Bovine
Applications
ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry, Immunoprecipitation, Western Blot
Purity
Purified by Epitope Affinity Purification
Synonyms
TIMP-4; Polyclonal Antibody; Rabbit anti TIMP-4 Polyclonal Antibody; TIMP metallopeptidase inhibitor 4; anti-TIMP-4 antibody
Host
Rabbit
Reactivity
Human, Rat, Mouse, Bovine
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody recognizes ~25 kDa of human TIMP-4 protein. This antibody reacts with human, rat, mouse. The other species are not tested.
Purity/Purification
Purified by Epitope Affinity Purification
Form/Format
Supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Sequence Length
224
Applicable Applications for anti-TIMP-4 antibody
ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes
ELISA: 0.01-0.1 ug/ml
Flow Cytometry: 5-10 ug/ml
Immunohistochemistry: 2-10 ug/ml
Immunoprecipitation: 2-5 ug/ml
Western Blot: 0.1-1 ug/ml
Flow Cytometry: 5-10 ug/ml
Immunohistochemistry: 2-10 ug/ml
Immunoprecipitation: 2-5 ug/ml
Western Blot: 0.1-1 ug/ml
Preparation
A synthetic peptide corresponding to C-term of human TIMP-4. This sequence is identical among human, rat, mouse, chicken, dog and bovine.
Preparation and Storage
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C. The antibodies can be stored at 2 degree C - 8 degree C for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
Related Product Information for anti-TIMP-4 antibody
Tissue Inhibitors of Metalloproteinases (TIMPs) inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMPs comprise a family of four members: TIMP1, 2, 3, 4. TIMP-1 and TIMP-2 have similar properties, while TIMP-3 and TIMP-4 are involved inflammation-induced apoptosis and in matrix turnover. TIMP-4 is overexpressed in pilocytic astrocytomas, cardiovascular tissue areas populated by abundant inflammatory cells, human blood derived lymphocytes, monocytes/macrophages and mast cells. The TIMP-4 and its putative partner CD63 are potential markers of the astroctic phenotype in patients with gliomas.
References
Rorive, S., et al. TIMP-4 and CD63: new prognostic biomarkers in human astrocytomas. Mod. Pathol. 23 (10), 1418-1428 (2010).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
25,593 Da
NCBI Official Full Name
TPA: metalloproteinase inhibitor 4
NCBI Official Symbol
TIMP4
NCBI Protein Information
metalloproteinase inhibitor 4
UniProt Protein Name
Metalloproteinase inhibitor 4
UniProt Gene Name
TIMP4
UniProt Synonym Gene Names
TIMP-4
Uniprot Description
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
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Product Notes
The TIMP-4 timp4 (Catalog #AAA460577) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti TIMP-4 Polyclonal Antibody reacts with Human, Rat, Mouse, Bovine and may cross-react with other species as described in the data sheet. AAA Biotech's TIMP-4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). ELISA: 0.01-0.1 ug/ml Flow Cytometry: 5-10 ug/ml Immunohistochemistry: 2-10 ug/ml Immunoprecipitation: 2-5 ug/ml Western Blot: 0.1-1 ug/ml. Researchers should empirically determine the suitability of the TIMP-4 timp4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIMP-4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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