Testing Data
Rabbit TGF-beta Receptor II Polyclonal Antibody
TGF-beta Receptor II Antibody
Appearance: Colorless liquid
Shelf Life: 12 months
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
receptor for TGF-beta; may play a role in lung maturation and response to hypoxia [RGD, Feb 2006]
Uniprot Description
TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (receptor); Membrane protein, integral; Protein kinase, TKL; Oncoprotein; EC 2.7.11.30; TKL group; STKR family; Type2 subfamily
Cellular Component: cell surface; integral to plasma membrane; cytoplasm; integral to membrane; caveola; cytosol; receptor complex; external side of plasma membrane; lipid raft
Molecular Function: protein homodimerization activity; glycosaminoglycan binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; transmembrane receptor protein serine/threonine kinase activity; transforming growth factor beta receptor activity; protein binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta binding; protein heterodimerization activity; SMAD binding; ATP binding; receptor signaling protein serine/threonine kinase activity
Biological Process: lens development in camera-type eye; wound healing; apoptosis; positive regulation of smooth muscle cell proliferation; heart development; myeloid dendritic cell differentiation; gastrulation; palate development; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; response to organic cyclic substance; response to organic substance; negative regulation of cell proliferation; negative regulation of cardiac muscle cell proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; transmembrane receptor protein serine/threonine kinase signaling pathway; response to glucose stimulus; positive regulation of NK T cell differentiation; vasculogenesis; response to nutrient; positive regulation of T cell tolerance induction; aging; response to drug; receptor-mediated endocytosis; smoothened signaling pathway; organ regeneration; positive regulation of skeletal muscle regeneration; in utero embryonic development; embryonic hemopoiesis; common-partner SMAD protein phosphorylation; peptidyl-threonine phosphorylation; embryonic cranial skeleton morphogenesis; regulation of cell proliferation; patterning of blood vessels; organ morphogenesis; peptidyl-serine phosphorylation; positive regulation of angiogenesis; gut development; response to estrogen stimulus; response to steroid hormone stimulus; regulation of gene expression; response to mechanical stimulus; cartilage development; positive regulation of B cell tolerance induction; activation of protein kinase activity; response to hypoxia; brain development; embryo implantation; lung development
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Product Notes
The TGF-beta Receptor II (Catalog #AAA840510) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TGF-beta Receptor II Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TGF-beta Receptor II can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). The antibody can be used for Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. Blocking peptide is available separately. Researchers should empirically determine the suitability of the TGF-beta Receptor II for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TGF-beta Receptor II, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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