Rabbit anti-Human CCR3 Polyclonal Antibody | anti-CCR3 antibody

CCR3 Antibody

Cat. Num. AAA840280

• Gene Names: Ccr3; Cmkbr3
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: CCR3; Polyclonal Antibody; CCR3 Antibody; CMKBR3; CKR3; CD193; CC-CKR-3; C CKR-3; CCR-3; anti-CCR3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: 100 ug (0.5 mg/ml) Protein G purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.; Appearance: Colorless liquid
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 359

• Applicable Applications for anti-CCR3 antibody: Western Blot (WB)
• Application Notes: Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually.
• Immunogen: Synthetic peptide surrounding amino acid 332 of rat CCR3
• Handling: The antibody solution should be gently mixed before use.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for anti-CCR3 antibody

Background: Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR3 (eotaxin receptor), is expressed on eosinophils and certain T cell population respond to a variety of CC chemokines apart from eotaxin, including RANTES, monocyte chemotactic protein (MCP)-2, MCP-3, and MCP-4. CCR3 facilitated infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, and inhibited infection by these isolates.

NCBI and Uniprot Product Information

• NCBI GI #: 16758844
• NCBI GeneID: 117027
• NCBI Accession #: NP_446410
• NCBI GenBank Nucleotide #: NM_053958.1
• Molecular Weight: 41,643 Da
• NCBI Official Full Name: C-C chemokine receptor type 3
• NCBI Official Synonym Full Names: chemokine (C-C motif) receptor 3
• NCBI Official Symbol: Ccr3
• NCBI Official Synonym Symbols: Cmkbr3
• NCBI Protein Information: C-C chemokine receptor type 3
• UniProt Protein Name: C-C chemokine receptor type 3
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: Ccr3
• UniProt Synonym Gene Names: Cmkbr3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3
• UniProt Entry Name: CCR3_RAT

NCBI Description

chemokine receptor; may have a role in inflammation and HIV infection [RGD, Feb 2006]

Uniprot Description

CCR3: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, cytokine; GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass

Cellular Component: extracellular space; integral to membrane; plasma membrane; endosome

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; mast cell chemotaxis; eosinophil chemotaxis; positive regulation of endothelial cell proliferation; inflammatory response; chemotaxis