Rabbit TCCR Polyclonal Antibody | anti-IL27RA antibody

TCCR, CT (T Cell Cytokine Receptor, WSX-1)

Cat. Num. AAA612625

• Gene Names: IL27RA; CRL1; TCCR; WSX1; IL27R; zcytor1; IL27RA
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: TCCR; Polyclonal Antibody; CT (T Cell Cytokine Receptor; WSX-1); Anti -TCCR; anti-IL27RA antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes TCCR, Mr ~70kD. Species Crossreactivity: Human, mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide, 40% glycerol.

• Applicable Applications for anti-IL27RA antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 0.5-1ug/ml
• Immunogen: Synthetic peptide (SGYEKHFLPTPEELG) corresponding to as611-625 of human TCCR precursor. This sequence is identical to that of mouse TCCR.
• Positive Control: Human spleen tissue lysate
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of TCCR expression in human spleen tissue lysates with anti-TCCR at 1ug/ml.)

Related Product Information for anti-IL27RA antibody

Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-g and lymphotoxin-b that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5 and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-g and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph nodes and peripheral blood leukocytes.

Product Categories/Family for anti-IL27RA antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 37182870
• NCBI GeneID: 9466
• UniProt Accession #: Q6UWB1; O60624; A0N0L1
• Molecular Weight: 69,474 Da
• NCBI Official Full Name: TCCR
• NCBI Official Synonym Full Names: interleukin 27 receptor, alpha
• NCBI Official Symbol: IL27RA
• NCBI Official Synonym Symbols: CRL1; TCCR; WSX1; IL27R; zcytor1; IL27RA
• NCBI Protein Information: interleukin-27 receptor subunit alpha; IL-27RA; IL-27R-alpha; IL-27R subunit alpha; cytokine receptor-like 1; class I cytokine receptor; IL-27 receptor subunit alpha; T-cell cytokine receptor type 1; type I T-cell cytokine receptor
• UniProt Protein Name: Interleukin-27 receptor subunit alpha
• Protein Family: Interleukin-27 receptor
• UniProt Gene Name: IL27RA
• UniProt Synonym Gene Names: CRL1; TCCR; WSX1
• UniProt Entry Name: I27RA_HUMAN

NCBI Description

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq]

Uniprot Description

IL27RA: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms. Belongs to the type I cytokine receptor family. Type 2 subfamily.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: integral to plasma membrane

Molecular Function: interleukin-27 receptor activity; transmembrane receptor activity

Biological Process: positive regulation of interferon-gamma production; defense response to Gram-positive bacterium; cell surface receptor linked signal transduction; negative regulation of T-helper 2 type immune response; positive regulation of T-helper 1 type immune response; immune response; regulation of isotype switching to IgG isotypes