Rabbit LIPC Polyclonal Antibody | anti-LIPC antibody

LIPC Polyclonal Antibody

Cat. Num. AAA3005913

• Gene Names: LIPC; HL; HTGL; LIPH; HDLCQ12
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: LIPC; Polyclonal Antibody; LIPC Polyclonal Antibody; Hepatic triacylglycerol lipase; Short name=HL; Hepatic lipase; Lipase member C; HTGL; anti-LIPC antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: LIPC polyclonal antibody detects endogenous levels of LIPC protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 499

• Applicable Applications for anti-LIPC antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to the 349-394 of Human LIPC.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of LIPC polyclonal antibody at 1:500 dilutionLane1:HEK293T cell lysateLane2:NIH-3T3 cell lysateLane3:H9C2 cell lysate)

Related Product Information for anti-LIPC antibody

The Lipase family belongs to one of the most robust genetic superfamilies found in living organisms that includes esterases and thioesterases. Lipase gene products are related by tertiary structure rather than primary amino acid sequence. Balancing the composition and the transport of lipoproteins in human plasma is essential for normal body function and is mediated in part by Hepatic Lipase, also known as HL or LIPC. Rare deficiencies in Hepatic Lipase have been identified in humans which lead to pathologic levels of circulating lipoprotein particles; this condition is associated with coronary artery disease (CAD). Hepatic Lipase is regulated by thyroid hormones and has a dual function as a triglyceride hydrolase and a ligand/bridging factor for receptor-mediated lipoprotein uptake. Hepatic Lipase localizes to the endothelial surfaces of extrahepatic tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 339595
• NCBI GeneID: 3990
• UniProt Accession #: P11150
• Molecular Weight: ~ 56kDa
• NCBI Official Full Name: triglyceride lipase
• NCBI Official Synonym Full Names: lipase C, hepatic type
• NCBI Official Symbol: LIPC
• NCBI Official Synonym Symbols: HL; HTGL; LIPH; HDLCQ12
• NCBI Protein Information: hepatic triacylglycerol lipase
• UniProt Protein Name: Hepatic triacylglycerol lipase
• Protein Family: Spore germination lipase
• UniProt Gene Name: LIPC
• UniProt Synonym Gene Names: HTGL; HL
• UniProt Entry Name: LIPC_HUMAN

NCBI Description

LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]

Uniprot Description

LIPC: Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. Defects in LIPC are the cause of hepatic lipase deficiency (HL deficiency). A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. Belongs to the AB hydrolase superfamily. Lipase family.

Protein type: Secreted, signal peptide; EC 3.1.1.3; Lipid Metabolism - glycerolipid; Phospholipase; Secreted

Chromosomal Location of Human Ortholog: 15q21-q23

Cellular Component: extracellular space

Molecular Function: heparin binding; triacylglycerol lipase activity; low-density lipoprotein binding; apolipoprotein binding; phospholipase activity

Biological Process: cholesterol metabolic process; cholesterol homeostasis; reverse cholesterol transport; triacylglycerol catabolic process; fatty acid biosynthetic process

Disease: High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 12; Hepatic Lipase Deficiency; Diabetes Mellitus, Noninsulin-dependent