SDS-Page
CFHR2 recombinant protein
CFHR2 Protein, Human, Recombinant (His Tag)
Gene Names
CFHR2; FHR2; HFL3; CFHL2
Purity
>90% as determined by SDS-PAGE
Synonyms
CFHR2; CFHR2 Protein; Human; Recombinant (His Tag); Human CFHR2/FHR2/HFL3 Protein (His Tag); CFHL2 Protein; FHR2 Protein; HFL3 Protein; complement factor H-related 2; CFHR2 recombinant protein
Host
HEK293 Cells
Purity/Purification
>90% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Sequence
Met1-Lys270
Species
Human
Endotoxin
<1.0EU per ug of the protein as determined by the LAL method
Predicted N Terminal
Glu 19
Tag
C-His
Protein Construction
A DNA sequence encoding the human CFHR2 (P36980-1)(Met1-Lys270) was expressed with a polyhistidine tag at the C-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
SDS-Page
SDS-Page
Related Product Information for CFHR2 recombinant protein
Background: CFHR2 belongs to the complement factor H protein family. The human complement factor H protein family consists of the complement and immune regulators factor H, the factor H-like protein 1(FHL-1) and five factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. CFHR2 contains 4 Sushi (CCP/SCR) domains and is expressed by the liver and secreted in plasma. CFHR2 might be involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism.
Product Categories/Family for CFHR2 recombinant protein
References
Skerka C, et al. (1991) Molecular cloning of a human serum protein structurally related to complement factor H. J Biol Chem. 266(18):12015-20.Daz-Guilln MA, et al. (1999) A radiation hybrid map of complement factor H and factor H-related genes. Immunogenetics. 49(6):549-52.Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
27,897 Da
NCBI Official Full Name
complement factor H-related protein 2 isoform 1
NCBI Official Synonym Full Names
complement factor H related 2
NCBI Official Symbol
CFHR2
NCBI Official Synonym Symbols
FHR2; HFL3; CFHL2
NCBI Protein Information
complement factor H-related protein 2
UniProt Protein Name
Complement factor H-related protein 2
Protein Family
UniProt Gene Name
CFHR2
UniProt Synonym Gene Names
CFHL2; FHR2; HFL3; FHR-2
NCBI Description
This gene belongs to a family of complement factor H-related genes (CFHR), which are clustered together with complement factor H gene on chromosome 1, and are involved in regulation of complement. Mutations in CFHR genes have been associated with dense deposit disease and atypical haemolytic-uraemic syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Description
Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.
Research Articles on CFHR2
1. Studies indicate an association between CFHR2-rs2986127 and acute anterior uveitis (AAU) diagnosis.
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Product Notes
The CFHR2 cfhr2 (Catalog #AAA8121584) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Met1-Lys27 0. It is sometimes possible for the material contained within the vial of "CFHR2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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