Rabbit anti-Human TAF4B Polyclonal Antibody | anti-TAF4B antibody

TAF4B, CT (TAF4B, TAF2C2, TAFII105, Transcription initiation factor TFIID subunit 4B, Transcription initiation factor TFIID 105kD subunit) (MaxLight 750)

Cat. Num. AAA6353400

• Gene Names: TAF4B; SPGF13; TAF2C2; TAFII105
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TAF4B; Polyclonal Antibody; CT (TAF4B; TAF2C2; TAFII105; Transcription initiation factor TFIID subunit 4B; Transcription initiation factor TFIID 105kD subunit) (MaxLight 750); Transcription initiation factor TFIID 105kD subunit; anti-TAF4B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-TAF4B antibody: Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)
• Application Notes: FC/FACS: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: TAF4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-683 amino acids from the C-terminal region of human TAF4B.
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-TAF4B antibody

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).

Product Categories/Family for anti-TAF4B antibody

Antibodies; Transcription Factors

References

Kalogeropoulou, M., et al. Mol. Cancer Res. 8(4):554-568(2010). Gazit, K., et al. J. Biol. Chem. 284(39):26286-26296(2009). Knauff, E.A., et al. Hum. Reprod. 24(9):2372-2378(2009). Teye, K., et al. Int. J. Oncol. 33(6):1271-1280(2008). Liu, W.L., et al. Mol. Cell 29(1):81-91(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 148792970
• NCBI GeneID: 6875
• NCBI Accession #: NP_005631.1
• NCBI GenBank Nucleotide #: NM_005640.1
• UniProt Accession #: Q92750; Q29YA4; Q29YA5
• Molecular Weight: 63,364 Da
• NCBI Official Full Name: transcription initiation factor TFIID subunit 4B isoform 2
• NCBI Official Synonym Full Names: TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
• NCBI Official Symbol: TAF4B
• NCBI Official Synonym Symbols: SPGF13; TAF2C2; TAFII105
• NCBI Protein Information: transcription initiation factor TFIID subunit 4B
• UniProt Protein Name: Transcription initiation factor TFIID subunit 4B
• Protein Family: Transcription initiation factor
• UniProt Gene Name: TAF4B
• UniProt Synonym Gene Names: TAF2C2; TAFII105; TAF(II)105; TAFII-105; TAFII105
• UniProt Entry Name: TAF4B_HUMAN

Uniprot Description

TAF4B: Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Belongs to the TAF4 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: nucleoplasm; transcription factor TFIID complex; cytoplasm; nucleolus

Molecular Function: NF-kappaB binding; DNA binding; protein heterodimerization activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; oogenesis; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; viral reproduction; RNA elongation from RNA polymerase II promoter; spermatogenesis; gene expression

Disease: Spermatogenic Failure 13