Rabbit anti-Human STRA8 Polyclonal Antibody | anti-STRA8 antibody

Anti-STRA8 Antibody, Rabbit Polyclonal

Cat. Num. AAA8100277

• Reactivity: Human
• Applications: Western Blot
• Purity: Protein A & Antigen Affinity
• Synonyms: STRA8; Polyclonal Antibody; Anti-STRA8 Antibody; Rabbit Polyclonal; STRA8 Antibody; Rabbit PAb; Antigen Affinity Purified; stimulated by retinoic acid gene 8; anti-STRA8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human STRA8
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-STRA8 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the N-terminus of the Human STRA8
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human STRA8, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Anti-STRA8 rabbit polyclonal antibody at 1:500 dilutionLane A: HEK293 Whole Cell LysateLane B: 293 Whole Cell LysateLysates/proteins at 30 ug per lane.SecondaryGoat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.Developed using the Odyssey technique. Performed under reducing conditions.Predicted band size:37 kDaObserved band size:35 kDa(We are unsure as to the identity of these extra bands.))

Related Product Information for anti-STRA8 antibody

Stimulated by retinoic acid gene 8 (STRA8) is specifically expressed in mammalian germ cells before their transition from mitosis to meiosis. STRA8 expression is observed only in the postnatal testis. Stra8 (stimulated by retinoic acid 8) encodes a protein crucial for mammalian germ cells entering into premeiotic stages. STRA8 associates with DNA and possesses transcriptional activity, and STRA8 can exert important functions in the nucleus.

NCBI and Uniprot Product Information

• NCBI GI #: 74713759
• NCBI GeneID: 346673
• UniProt Accession #: Q7Z7C7
• Molecular Weight: 36,908 Da
• NCBI Official Full Name: Stimulated by retinoic acid gene 8 protein homolog
• NCBI Official Synonym Full Names: stimulated by retinoic acid 8
• NCBI Official Symbol: STRA8
• NCBI Protein Information: stimulated by retinoic acid gene 8 protein homolog; STRA8 {ECO:0000312|EMBL:AAP47163.1}; stimulated by retinoic acid 8 homolog; stimulated by retinoic acid gene 8 homolog
• UniProt Protein Name: Stimulated by retinoic acid gene 8 protein homolog
• Protein Family: Stimulated by retinoic acid gene 8 protein
• UniProt Gene Name: STRA8
• UniProt Entry Name: STRA8_HUMAN

NCBI Description

This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]

Uniprot Description

STRA8: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase.

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: cytoplasm; nucleus

Molecular Function: protein dimerization activity

Biological Process: fertilization; meiotic cell cycle DNA replication checkpoint; ovarian follicle development; meiotic chromosome condensation; meiotic recombination; synapsis; meiotic DNA double-strand break formation; spermatogenesis; regulation of organ growth; female meiosis sister chromatid cohesion; DNA replication; oocyte development